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Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: Therapeutic implications
(2009)
Early models for the etiology of schizophrenia focused on dopamine neurotransmission because of the powerful anti-psychotic action of dopamine antagonists. Nevertheless, recent evidence increasingly supports a primarily ...
From glutamatergic dysfunction to cognitive impairment: Boundaries in the therapeutic of the schizophrenia
(Bentham Science, 2012)
Cognitive deficits are trait markers in schizophrenia and the improvement of these dysfunctions has been considered as a new frontier of treatment in this disease. A current model for the patophysiology of schizophrenia ...
Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex
(SPRINGERDORDRECHT, 2012)
Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic ...
Avaliação crônica de aspectos neuroinflamatórios, cognitivos e de memória em modelo murino tratado com dieta hiperpalatável
(Universidade Federal de Minas GeraisBrasilPrograma de Pós-Graduação em NeurociênciasUFMG, 2022-12-27)
Excessive consumption of hyperpalatable and hypercaloric food has been pointed out as a
factor associated with cognitive decline and memory impairment in obesity. In this context, it
is known that the integration between ...
Expressão de GABA e plasticidade do fenótipo neuroquímico e morfológico de células da Zona Subventricular pós-natal
(Brasil, 2008)
The subventricular zone (SVZ) is proliferative epithelium that continuously gives rise to new neurons in postnatal and adult mammals. The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) where ...
The Integration of the Glutamatergic and the White Matter Hypotheses of Schizophrenia's Etiology
(BENTHAM SCIENCE PUBL LTDSHARJAH, 2012)
Background: schizophrenia's endophenotipic profile is not only generally complex, but often varies from case to case. The perspective of trying to define specific anatomic correlates of the syndrome has led to disappointing ...
Systematic review of N-acetylcysteine in the treatment of addictions
(Associação Brasileira de Psiquiatria - ABP, 2014-05-13)
Objective: To conduct the first systematic literature review of clinical trials of N-acetylcysteine (NAC) for the treatment of substance abuse disorders and addictive behaviors. Methods: A search of the MEDLINE, Embase and ...
Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning
(Elsevier B.V., 2008-09-30)
A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of ...
Cholinergic and glutamatergic agonists induce gamma frequency activity in dorsal subcoeruleus nucleus neurons
(American Physiological Society, 2011-05)
The dorsal subcoeruleus nucleus (SubCD) is involved in generating two signs of rapid eye movement (REM) sleep: muscle atonia and ponto-geniculo-occipital (PGO) waves. We tested the hypothesis that single cell and/or ...
El sistema glutamatérgico como una nueva diana para fármacos antidepresivos más eficacesThe glutamatergic system as a new target for more efficaceous antidepressants
(Academia Argentina de Farmacia y Bioquímica, 2015-12)
La hipótesis monoaminérgica de los trastornos de los estados de ánimo (depresión mayor y depresión bipolar) proponía que éstos podrían ser la consecuencia de un déficit funcional, o de un desbalance, de las aminas biógenas ...