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Estrogen receptors mediate rapid activation of phospholipase C pathway in the rat endometrium
(Elsevier B.V., 2011-12-20)
The aim of the present study was to investigate the activation of rapid signaling events by 17 beta-estradiol in the rat uterus. 17 beta-Estradiol induced a rapid increase of total [(3)H]-inositol phosphate accumulation ...
Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production.
(Elsevier Ireland, 2016-02)
Intracellular renin-angiotensin system (RAS) can operate independently of the circulating RAS. Estrogens provide protective effects by modulating the RAS. Our aim was to investigate the effect of estradiol (E2) on angiotensin ...
Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae)
(Journal of Ethnopharmacology 129(2): 220–226, 2010)
Ethnopharmacological relevance: Our previous work has demonstrated that several plants in the Piperaceae family are commonly used by the Q’eqchi Maya of Livingston, Guatemala to treat amenorrhea,
dysmenorrhea, and pain. ...
Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae)
(Journal of Ethnopharmacology 129(2): 220–226, 2010)
Ethnopharmacological relevance: Our previous work has demonstrated that several plants in the Piperaceae family are commonly used by the Q’eqchi Maya of Livingston, Guatemala to treat amenorrhea,
dysmenorrhea, and pain. ...
The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor
(Elsevier Ireland, 2015-11)
Fulvestrant, a selective estrogen receptor down-regulator (SERD) is a pure competitive antagonist of estrogen receptor alpha (ERα). Fulvestrant binds ERα and reduces the receptor's half-life by increasing protein turnover, ...
Apoptosis of Lactotrophs Induced by D2 Receptor Activation Is Estrogen Dependent
(Karger, 2008-02)
BACKGROUND/AIMS: Dopamine (DA) inhibits prolactin release and reduces lactotroph proliferation by activating D2 receptors. DA and its metabolite, 6-hydroxydopamine (6-OHDA), induce apoptosis in different cell types. DA ...
Estradiol stimulates cell proliferation via classic estrogen receptor-alpha and G protein-coupled estrogen receptor-1 in human renal tubular epithelial cell primary cultures
(Academic Press Inc Elsevier Science, 2019-04)
This work was aimed to determine the effect of 17β-estradiol (17βE) on cell proliferation in human renal tubular epithelial cells (HRTEC) isolated from kidneys from pediatric subjects, as well as the role of estrogen ...
Estradiol`s Salutary Effects on Keratinocytes Following Trauma-Hemorrhage Are Mediated by Estrogen Receptor (ER)-alpha and ER-beta
(FEINSTEIN INST MED RES, 2008)
Although administration of 17 beta-estradiol (estrogen) following trauma-hemorrhage attenuates the elevation of cytokine production and mitogen-activated protein kinase (MAPK) activation in epidermal keratinocytes, whether ...