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Tomato ABSCISIC ACID STRESS RIPENING (ASR) Gene Family Revisited
(Public Library of Science, 2014-10)
Tomato ABSCISIC ACID RIPENING 1 (ASR1) was the first cloned plant ASR gene. ASR orthologs were then cloned from a large number of monocot, dicot and gymnosperm plants, where they are mostly involved in response to abiotic ...
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
(Nature, 2014-05)
Inhibition of distinct ubiquitin E3 ligases might represent a powerful therapeutic tool. ITCH is a HECT domain-containing E3 ligase that promotes the ubiquitylation and degradation of several proteins, including p73, p63, ...
Role of the endocannabinoid system in the neuroendocrine responses to inflammation
(Bentham Science Publishers, 2014-02)
A few years ago the endocannabinoid system has been recognized as a major neuromodulatory system whose main functions are to exert and maintain the body homeostasis. Several different endocannabinoids are synthesized in a ...
Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy against a Murine Melanoma In Vivo
(2014)
Immune-based anti-tumor or anti-angiogenic therapies hold considerable promise for the treatment of cancer. The first approach seeks to activate tumor antigen-specific T lymphocytes while, the second, delays tumor growth ...
PKA-chromatin association at stress responsive target genes from Saccharomyces cerevisiae
(Elsevier Science, 2015-11)
Gene expression regulation by intracellular stimulus-activated protein kinases is essential for cell adaptation to environmental changes. There are three PKA catalytic subunits in Saccharomyces cerevisiae: Tpk1, Tpk2, and ...
The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM
(Company of Biologists, 2016-11)
The formation of synaptic connections during nervous system development requires the precise control of dendrite growth and synapse formation. Although glial cell line-derived neurotrophic factor (GDNF) and its receptor ...
Modular unfolding and dissociation of the human respiratory syncytial virus phosphoprotein p and its interaction with the m(2-1) antiterminator: a singular tetramer-tetramer interface arrangement
(American Chemical Society, 2012-10)
Paramyxoviruses share the essential RNA polymerase complex components, namely, the polymerase (L), phosphoprotein (P), and nucleoprotein (N). Human respiratory syncytial virus (RSV) P is the smallest polypeptide among the ...
Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis.
(Wiley, 2014-06-30)
Endometriosis is characterized by the presence of endometrial tissue outside the uterus that causes severe pelvic pain and infertility in women of reproductive age. Although not completely understood, the pathophysiology ...
Cellular Remodelling by Apoptosis During Porcine Placentation
(Wiley VCH Verlag, 2013-02)
The mechanisms that regulate the apoptosis are essential to the normal development and maintenance of homoeostasis and play an important role in placental development in mammals. During porcine pregnancy, there must be a ...
Characterization of the mature cell surface proteinase of Lactobacillus delbrueckii subsp. lactis CRL 581
(Springer Verlag Berlín, 2015-05)
The cell envelope-associated proteinase (CEP) of Lactobacillus delbrueckii subsp. lactis CRL 581 (PrtL) has an essential role in bacterial growth, contributes to the flavor and texture development of fermented products, ...