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Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA
(WILEY-BLACKWELL, 2008)
The protein phosphatase calcineurin is an important mediator connecting calcium-dependent signalling to various cellular responses in multiple organisms. In fungi calcineurin acts largely through regulating Crz1p-like ...
Increased levels of cyclin D1 negatively impacts on acute lymphoblastic leukemia overall survival
(BioMed Central, 2018)
Abstract
Background
Cyclin D1 is a protein essential for transition from G1 to S phase during cell cycle progression, which has an oncogenic potential and is highly expressed ...
Overexpression of Cytoplasmic TcSIR2RP1 and Mitochondrial TcSIR2RP3 Impacts on Trypanosoma cruzi Growth and Cell Invasion
(Public Library of Science, 2015-04)
Background: Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets ...
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner
(Public Library of Science, 2016-11)
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and to thus modulate inflammatory processes. This study demonstrates ...
Longipin: An amyloid antimicrobial peptide from the harvestman Acutisoma longipes (Arachnida: Opiliones) with preferential affinity for anionic vesicles
(Public Library of Science, 2016-12)
In contrast to vertebrate immune systems, invertebrates lack an adaptive response and rely solely on innate immunity in which antimicrobial peptides (AMPs) play an essential role. Most of them are membrane active molecules ...
Cell-cell communication between Mouse mammary epithelial cells and 3T3-L1 preadipocytes: effect on triglyceride accumulation and cell proliferation
(Instituto de Histología y Embriología, 2007-08)
Interaction between parenchyma and stroma is essential for organogenesis, morphogenesis, and differentiation. Mammary gland has being the chosen model for developmental biologist because the most striking changes in ...
Mammalian Staufen 1 is recruited to stress granules and impairs their assembly
(Company of Biologists, 2009-02)
Stress granules are cytoplasmic mRNA-silencing foci that form transiently during the stress response. Stress granules harbor abortive translation initiation complexes and are in dynamic equilibrium with translating polysomes. ...
Extensive identification of bacterial riboflavin transporters and their distribution across bacterial species
(Public Library Of Science, 2015-05)
Riboflavin, the precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide, is an essential metabolite in all organisms. While the functions for de novo riboflavin biosynthesis and riboflavin ...
Blockade of a key region in the extracellular domain inhibits HER2 dimerization and signaling
(Oxford Univ Press Inc, 2015-04-17)
Background: Several treatment strategies target the human epidermal growth factor receptor 2 (HER2) in breast carcinomas, including monoclonal antibodies directed against HER2?s extracellular domain (ECD) and small molecule ...
Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells
(Public Library Science, 2013-01)
Gangliosides are sialic acid-containing glycolipids expressed on plasma membranes from nearly all vertebrate cells. The expression of ganglioside GD3, which plays essential roles in normal brain development, decreases in ...