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        Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA 

        SORIANI, Frederico Marianetti; MALAVAZI, Iran; FERREIRA, Marcia Eliana da Silva; SAVOLDI, Marcela; KRESS, Marcia Regina Von Zeska; GOLDMAN, Maria Helena de Souza; LOSS, Omar; BIGNELL, Elaine; GOLDMAN, Gustavo Henrique (WILEY-BLACKWELL, 2008)
        The protein phosphatase calcineurin is an important mediator connecting calcium-dependent signalling to various cellular responses in multiple organisms. In fungi calcineurin acts largely through regulating Crz1p-like ...

        Increased levels of cyclin D1 negatively impacts on acute lymphoblastic leukemia overall survival 

        Fernandes, Jaqueline Cristina; Alves, Ana Paula Nunes Rodrigues; Silva, Juan Luiz Coelho da; Ribeiro, Renata Scopim; Fenerich, Bruna Alves; Simoes, Belinda Pinto; Rego, Eduardo Magalhães; Machado Neto, João Agostinho; Traina, Fabíola (BioMed Central, 2018)
        Abstract Background Cyclin D1 is a protein essential for transition from G1 to S phase during cell cycle progression, which has an oncogenic potential and is highly expressed ...

        Overexpression of Cytoplasmic TcSIR2RP1 and Mitochondrial TcSIR2RP3 Impacts on Trypanosoma cruzi Growth and Cell Invasion 

        Ritagliati, Carla; Alonso, Victoria Lucia; Manarin, Romina; Cribb, Pamela; Serra, Esteban Carlos (Public Library of Science, 2015-04)
        Background: Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets ...

        Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner 

        Errea, Agustina Juliana; Cayet, Delphine; Marchetti, Philippe; Tang, Cong; Kluza, Jerome; Offermanns, Stefan; Sirard, Jean Claude; Rumbo, Martín (Public Library of Science, 2016-11)
        Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and to thus modulate inflammatory processes. This study demonstrates ...

        Longipin: An amyloid antimicrobial peptide from the harvestman Acutisoma longipes (Arachnida: Opiliones) with preferential affinity for anionic vesicles 

        Sayegh, Raphael Santa Rosa; De Fatima Correia Batista, Isabel; De Melo, Robson Lopes; Riske, Karin A.; Daffre, Sirlei; Montich, Guillermo Gabriel; Da Silva Junior, Pedro Ismael (Public Library of Science, 2016-12)
        In contrast to vertebrate immune systems, invertebrates lack an adaptive response and rely solely on innate immunity in which antimicrobial peptides (AMPs) play an essential role. Most of them are membrane active molecules ...

        Cell-cell communication between Mouse mammary epithelial cells and 3T3-L1 preadipocytes: effect on triglyceride accumulation and cell proliferation 

        Julianelli, Vanina Laura; Guerra, Liliana Noemi; Calvo, Juan Carlos (Instituto de Histología y Embriología, 2007-08)
        Interaction between parenchyma and stroma is essential for organogenesis, morphogenesis, and differentiation. Mammary gland has being the chosen model for developmental biologist because the most striking changes in ...

        Mammalian Staufen 1 is recruited to stress granules and impairs their assembly 

        Thomas, Maria Gabriela; Martínez Tosar, Leandro Julián; Desbats, Maria Andrea; Leishman, Claudia; Boccaccio, Graciela Lidia (Company of Biologists, 2009-02)
        Stress granules are cytoplasmic mRNA-silencing foci that form transiently during the stress response. Stress granules harbor abortive translation initiation complexes and are in dynamic equilibrium with translating polysomes. ...

        Extensive identification of bacterial riboflavin transporters and their distribution across bacterial species 

        Gutiérrez Preciado, Ana; Torres, Alfredo Gabriel; Merino, Enrique; Bonomi, Hernan Ruy; Goldbaum, Fernando Alberto; García Angulo, Víctor Antonio (Public Library Of Science, 2015-05)
        Riboflavin, the precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide, is an essential metabolite in all organisms. While the functions for de novo riboflavin biosynthesis and riboflavin ...

        Blockade of a key region in the extracellular domain inhibits HER2 dimerization and signaling 

        Menendez, Javier; Schroeder, Barbara; Peirce, Susan K.; Vellón, Luciano; Papadimitropoulou, Adriana; Espinoza, Ingrid; Lupu, Ruth (Oxford Univ Press Inc, 2015-04-17)
        Background: Several treatment strategies target the human epidermal growth factor receptor 2 (HER2) in breast carcinomas, including monoclonal antibodies directed against HER2?s extracellular domain (ECD) and small molecule ...

        Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells 

        Torres Demichelis, Vanina Andrea; Vilcaes, Aldo Alejandro; Iglesias Bartolome, Ramiro; Ruggiero, Fernando Miguel; Daniotti, Jose Luis (Public Library Science, 2013-01)
        Gangliosides are sialic acid-containing glycolipids expressed on plasma membranes from nearly all vertebrate cells. The expression of ganglioside GD3, which plays essential roles in normal brain development, decreases in ...
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        Red de Repositorios Latinoamericanos
        + of 4.000.000
        Available publications
        163 Participating institutions
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Membership Login
        Featured collections
        • Latin American Theses
        • Argentinean Theses
        • Chilean Theses
        • Peruvian Theses
        Latest collections added
        • Argentina
        • Brazil
        • Colombia
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        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018