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Nlrp3 activation and its relationship to endothelial dysfunction and oxidative stress: Implications for preeclampsia and pharmacological interventions
(2021-11-01)
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating ...
Changes in regional cerebral blood flow are associated with endothelial dysfunction markers in cocaine-dependent patients under recent abstinence
(Lippincott Williams and Wilkins, 2015)
© 2015 American Society of Addiction Medicine. Objectives: Cocaine is a known risk factor for several vascular ischemic events. The underlying mechanisms leading to the complications are not fully understood, although ...
ENDOTHELIAL DYSFUNCTION IN CORONARY VESSELS AND THORACIC AORTA OF RATS EXPOSED TO CIGARETTE-SMOKE
(Blackwell Science Publ AustrCarltonAustralia, 1995)
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature
(2018)
Maternal physiological or supraphysiological hypercholesterolemia (MPH, MSPH) occurs during pregnancy. MSPH is associated with foetal endothelial dysfunction and atherosclerosis. However, the potential effects of MSPH on ...
Tetrahydrobiopterin Role In Human Umbilical Vein Endothelial Dysfunction In Maternal Supraphysiological Hypercholesterolemia
(2016)
Maternal physiological hypercholesterolemia (MPH) allows a proper foetal development; however, maternal supraphysiological hypercholesterolemia (MSPH) associates with foetal endothelial dysfunction and early development ...
Human Maternal Supraphysiological Hypercholesterolemia Leads To Endothelial Dysfunction Of The Placental Microvasculature
(2017)
Maternal physiological hypercholesterolemia (MPH) occurs in pregnancy assuring foetal development. However, maternal supraphysiological hypercholesterolemia (MSPH) leads to endothelial dysfunction in the umbilical vein. ...
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits
(Springer, 2014-07)
The present study evaluatedthe plasma fatty acidlevels and thevascular prostaglandin releaseina rabbit model of early hypercholesterolemia with endothelial dysfunction. Rabbits were fed either a control diet (CD) or a diet ...
In vivo vascular rarefaction and hypertension induced by dexamethasone are related to phosphatase PTP1B activation not endothelial metabolic changes
(2020-05-20)
Glucocorticoids have important anti-inflammatory and immunomodulatory activities. Dexamethasone (Dex), a synthetic glucocorticoid, induces insulin resistance, hyperglycemia, and hypertension. The hypertensive mechanisms ...
Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway
(Lippincott Williams and Wilkins, 2015)
© 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins.Objective: To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. ...
Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity
(Elsevier Ltd, 2014)
Endothelial dysfunction is decisive and leads to the development of several inflammatory diseases. Endotoxemia-derived sepsis syndrome exhibits a broad inflammation-induced endothelial dysfunction. We reported previously ...