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Ocular toxicity of intravitreous adalimumab (Humira) in the rabbit
(SPRINGER, 2008)
Purpose To evaluate the ocular toxicity of escalating doses of intravitreous adalimumab (Humira) in the rabbit eye. Methods Twelve New Zealand albino rabbits received unilateral intravitreous injections of 0.1 ml of ...
Phosphene Thresholds Elicited by Transcorneal Electrical Stimulation in Healthy Subjects and Patients with Retinal Diseases
(ASSOC RESEARCH VISION OPHTHALMOLOGY INCROCKVILLE, 2012)
PURPOSE. To evaluate electrically evoked phosphene thresholds (EPTs) in healthy subjects and in patients with retinal disease and to assess repeatability and possible correlations with common ophthalmologic tests. METHODS. ...
Transcorneal Electrical Stimulation Shows Neuroprotective Effects in Retinas of Light-Exposed Rats
(ASSOC RESEARCH VISION OPHTHALMOLOGY INCROCKVILLE, 2012-08-15)
PURPOSE. To examine the effects of transcorneal electrical stimulation (TES) on retinal degeneration of light-exposed rats. METHODS. Thirty-three Sprague Dawley albino rats were divided into three groups: STIM (n = 15) ...
Toxicity of High-Dose Intravitreal Adalimumab (Humira) in the Rabbit
(MARY ANN LIEBERT INC, 2011)
Purpose: To evaluate the ocular toxicity of escalating doses of intravitreous adalimumab (Humira (R)) in the rabbit eye. Methods: Thirty New Zealand albino rabbits received intravitreous injections of 0.5mg (6 eyes), 1.0mg ...
Effect of retinal ischemia on the non-image forming visual system
(Taylor & Francis, 2014-09)
Retinal ischemic injury is an important cause of visual impairment. The loss of retinal ganglion cells (RGCs) is a key sign of retinal ischemic damage. A subset of RGCs expressing the photopigment melanopsin (mRGCs) regulates ...
Post-ischemic environmental enrichment protects the retina from ischemic damage in adult rats
(Elsevier, 2013-02)
The aim of this study was to elucidate whether post-ischemic enriched environment (EE) housing protects the retina from ischemic damage in adult rats, and the involvement of glutamate in retinal protection induced by EE ...
Global and Ocular Hypothermic Preconditioning Protect the Rat Retina from Ischemic Damage
(Public Library Science, 2013-04)
Retinal ischemia could provoke blindness. At present, there is no effective treatment against retinal ischemic damage.
Strong evidence supports that glutamate is implicated in retinal ischemic damage. We investigated ...
Hypothermia Prevents Retinal Damage Generated by Optic Nerve Trauma in the Rat
(Nature Publishing Group, 2017-12)
Ocular and periocular traumatisms may result in loss of vision. Hypothermia provides a beneficial intervention for brain and heart conditions and, here, we study whether hypothermia can prevent retinal damage caused by ...
Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation
(Wiley, 2014-12)
Background and Purpose: Uveitis is a prevalent intraocular inflammatory disease and one of the most damaging ocular conditions. Pretreatment with melatonin prevented ocular inflammation induced by an intravitreal injection ...
Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice
(BioMed Central, 2016)
Diabetic retinopathy is a common complication of diabetes and the leading cause of irreversible vision loss in the Western world. The reduction in color/contrast sensitivity due to the loss of neural cells in the ganglion ...