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The importance of bioactivation in computer-guided drug repositioning: Why the parent drug is not always enough
(Bentham Science Publishers, 2016-08)
Although bioactivation is a well-documented process and the role of active metabolites in the drug discovery field has long been recognized, drug metabolites are usually ignored in virtual screening campaigns oriented to ...
High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease
(Bentham Science Publishers, 2015-03)
Despite affecting around 8 million people worldwide and representing an economic burden above $7 billion/ year, currently approved medications to treat Chagas disease are still limited to two drugs, nifurtimox and benznidazole, ...
New drugs are not enough-drug repositioning in oncology: An update
(Spandidos Publications, 2020-01)
Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that are already known for use treating other diseases. The advantages of this are that several important drug characteristics are ...
Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
(Crimson Publisher, 2019-05)
Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosed in advanced stages, when the development of resistance to chemotherapy is more frequent. To face this situation, new drugs ...
Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning
(Bentham Science Publishers, 2019)
In silico drug repositioning for chagas disease
(Bentham Science Publishers, 2020)
Chagas disease is an infectious tropical disease included within the group of neglected tropical diseases. Though historically endemic to Latin America, it has lately spread to high-income countries due to human migration. ...
Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
(Informa Healthcare, 2019-12)
Drug repurposing(or repositioning) implies finding new therapeutic indications for existingdrugs (including approved, failed, discontinued and experimental drugs), andrepresents a substantial percentage of recent drug ...
Drug repositioning: current approaches and their implications in the precision medicine era
(Taylor & Francis, 2018-01)
Introduction: Drug repositioning implies finding new medical uses for existing drugs. It represents a cost-efficient approach, since the new indications are built on the basis of available information on pharmacokinetics, ...
The importance of drug repurposing in the field of antiepileptic drug development
(Springer, 2016)
Drug repurposing involves finding new therapeutic uses for existing drugs, including marketed, discontinued, shelved, and investigational drugs. The advantages of this strategy are many: reduced drug development timeline, ...