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Self-Assembly Drugs: From Micelles to Nanomedicine
(Bentham Science Publishers, 2014)
Second-line drug susceptibility breakpoints for Mycobacterium tuberculosis using the MODS assay
(International Union Against Tuberculosis and Lung Disease, 2014)
OBJECTIVE: To establish breakpoint concentrations for the fluoroquinolones (moxifloxacin [MFX] and ofloxacin [OFX]) and injectable second-line drugs (amikacin [AMK], kanamycin [KM] and capreomycin [CPM]) using the microscopic ...
Incidence of virological failure and major regimen change of initial combination antiretroviral therapy in the Latin America and the Caribbean: An observational cohort study
(Elsevier, 2015)
Background: Access to combination antiretroviral therapy (ART) is expanding in Latin America (Mexico, Central America, and South America) and the Caribbean. We assessed the incidence of and factors associated with regimen ...
High throughput method to characterize acid-base properties of insoluble drug candidates in water
(Elsevier Science, 2018-05)
In drug design experimental characterization of acidic groups in candidate molecules is one of the more important steps prior to the in-vivo studies. Potentiometry combined with Yasuda-Shedlovsky extrapolation is one of ...
Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles
(Elsevier, 2021-01-01)
The possibility to conjugate tumor-targeted cytotoxic nanoparticles and conventional antitumoral drugs in single pharmacological entities would open a wide spectrum of opportunities in nanomedical oncology. This principle ...
Quantum chemical approaches in structure-based virtual screening and lead optimization
(Frontiers Research Foundation, 2018-05)
Today computational chemistry is a consolidated tool in drug lead discovery endeavors. Due to methodological developments and to the enormous advance in computer hardware, methods based on quantum mechanics (QM) have gained ...
Target-Pathogen: A structural bioinformatic approach to prioritize drug targets in pathogens
(Oxford University Press, 2018-01)
Available genomic data for pathogens has created new opportunities for drug discovery and development to fight them, including new resistant and multiresistant strains. In particular structural data must be integrated with ...
Computational chemistry in drug lead discovery and design
(John Wiley & Sons Inc., 2019-01)
The main contributions of our group during the last 15 years developing and using biomolecular simulation tools in drug lead discovery and design, in close collaboration with experimental researchers, are presented. Special ...
Polymer-based carriers for opthalmic drug delivery
(Elsevier Science, 2018-09)
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being explored to develop colloidal drug carriers ...
Rational design of polymer-lipid nanoparticles for docetaxel delivery
(Elsevier Science, 2019-03)
In this work, a stable nanocarrier for the anti-cancer drug docetaxel was rational designed. The nanocarrier was developed based on the solid lipid nanoparticle preparation process aiming to minimize the total amount of ...