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Now showing items 31-40 of 143
Relevance of the N-terminal and major hydrophobic domains of non-structural protein 3A in the replicative process of a DNA-launched foot-and-mouth disease virus replicon
(Springer Wien, 2018-07)
A foot-and-mouth disease virus (FMDV) DNA-launched reporter replicon containing a luciferase gene was used to assess the impact of non-structural (NS) protein 3A on viral replication. Independent deletions within the ...
Dehydration of llama sperm using different osmolarity media and temperatures for preservation
(Elsevier Science, 2021-02)
The objective of this study was to evaluate effects of dehydration on sperm DNA with the aim of eventually using this method for preserving llama spermatozoa. Two experiments were conducted: 1) sperm preservation at 5 °C ...
PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?
(Elsevier Science, 2010-04)
While many are the examples of DNA damaging treatments that induce p21 accumulation, the conception of p21 upregulation as the universal response to genotoxic stress has come to an end. Compelling evidences have demonstrated ...
Elucidating genomic patterns and recombination events in plant cybrid mitochondria
(Springer, 2019-04)
Key message: Cybrid plant mitochondria undergo homologous recombination, mainly BIR, keep a single allele for each gene, and maintain exclusive sequences of each parent and a single copy of the homologous regions. Abstract: ...
DNA related enzymes as molecular targets for antiviral and antitumoral chemotherapy. A natural overview of the current perspectives
(Bentham Science Publishers, 2019-01)
Background: The discovery of new chemotherapeutic agents still remains a continuous goal to achieve. DNA polymerases and topoisomerases act in nucleic acids metabolism modulating different processes like replication, ...
DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide
(American Society for Microbiology, 2001-04)
The activation of innate immune responses by genomic DNA from bacteria and several nonvertebrate organisms represents a novel mechanism of pathogen recognition. We recently demonstrated the CpG-dependent mitogenic activity ...
Analysis of fitness differences of hepatitis B virus genotypes D and F using a cotransfection assay
(Springer Wien, 2019-02)
Hepatitis B virus (HBV) circulates as a collection of genetically related variants that evolve throughout the chronic infection. Those viral variants that have the greatest ftness are fxed. We recently showed diferent ...
Role of viral load in Hepatitis B virus evolution in persistently normal ALT chronically infected patients
(Elsevier Science, 2019-01)
Chronic HBV infection has been associated with severe liver disease although most of them do not progress to this stage. Even though low replicative carriers form the largest group of HBV chronically infected patients, ...
A quasi-spontaneous amyloid route in a DNA binding gene regulatory domain: The papillomavirus HPV16 E2 protein
(Wiley, 2007-12)
The DNA binding domain of papillomavirus E2 proteins is at the center of the regulation of gene transcription and replication of the virus. Its unique fold consists of a beta-barrel domain that combines an eight-stranded ...
Evaluation of ATM Kinase inhibitor KU-55933 as potential anti-Toxoplasma gondii agent
(Frontiers Media S.A., 2019-02)
Toxoplasma gondii is an apicomplexan protozoan parasite with a complex life cycle composed of multiple stages that infect mammals and birds. Tachyzoites rapidly replicate within host cells to produce acute infection during ...