Search
Now showing items 31-40 of 1684
The arabidopsis DNA polymerase δ has a role in the deposition of transcriptionally active epigenetic marks, development and flowering
(Public Library Of Science, 2015-02)
DNA replication is a key process in living organisms. DNA polymerase α (Polα) initiates strand synthesis, which is performed by Polε and Polδ in leading and lagging strands, respectively. Whereas loss of DNA polymerase ...
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
(NATURE PUBLISHING GROUPLONDON, 2012)
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylating downstream effectors. Although there has been a concerted effort to identify effectors of Chk1 activity, underlying mechanisms of ...
UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability
(Oxford University Press, 2013-05)
Although many genotoxic treatments upregulate the cyclin kinase inhibitor p21, agents such as UV irradiation trigger p21 degradation. This suggests that p21 blocks a process relevant for the cellular response to UV. Here, ...
Replication Protein A presents canonical functions and is also involved in the differentiation capacity of Trypanosoma cruzi
(Instituto de Investigaciones Biotecnológicas, 2017)
Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome
(Elsevier, 2014-02)
Ultraviolet (UV)-induced DNA damage are removed by nucleotide excision repair (NER) or can be tolerated by specialized translesion synthesis (TLS) polymerases, such as Polη. TLS may act at stalled replication forks or ...
Inhibition of Cell Division and DNA Replication Impair Mouse-Naïve Pluripotency Exit
(Academic Press Ltd - Elsevier Science Ltd, 2017-09)
The cell cycle has gained attention as a key determinant for cell fate decisions, but the contribution of DNA replication and mitosis in stem cell differentiation has not been extensively studied. To understand if these ...
Evolution of the Metazoan Mitochondrial Replicase
(Oxford Univ Press, 2015-04-01)
The large number of complete mitochondrial DNA (mtDNA) sequences available for metazoan species makes it a good system for studying genome diversity, although little is known about the mechanisms that promote and/or are ...