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Maintaining Epigenetic Inheritance During DNA Replication in Plants
(Frontiers, 2016-02)
Biotic and abiotic stresses alter the pattern of gene expression in plants. Depending on the frequency and duration of stress events, the effects on the transcriptional state of genes are "remembered" temporally or transmitted ...
A new nonlinear DNA model
(Facultad Experimental de Ciencias de la Universidad del Zulia, 2011)
Bleomycin-induced γH2AX foci map preferentially to replicating domains in CHO9 interphase nuclei
(Kluwer Academic Publishers, 2014)
© 2014, Springer Science+Business Media Dordrecht.Exposure to DNA damaging agents triggers phosphorylation of histone variant H2AX (generating γH2AX) in large chromatin regions flanking DNA lesions, allowing their ...
Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ
(2021-11-01)
The COVID-19 pandemic prompted the FDA to authorize a new nucleoside analogue, remdesivir, for emergency use in affected individuals. We examined the effects of its active metabolite, remdesivir triphosphate (RTP), on the ...
MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity
(Oxford University Press, 2016-09)
Translesion DNA polymerases (Pol) function in the bypass of template lesions to relieve stalled replication forks but also display potentially deleterious mutagenic phenotypes that contribute to antibiotic resistance in ...
Mechanism of DNA Recognition at a Viral Replication Origin
(American Society for Biochemistry and Molecular Biology, 2006-09)
Recognition of the DNA origin by the Epstein-Barr nuclear antigen 1 (EBNA1) protein is the primary event in latentphase genome replication of the Epstein-Barr virus, a model for replication initiation in eukaryotes. We ...
Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA
(National Academy of Sciences, 2012-05)
The checkpoint kinases Chk1 and ATR are broadly known for their role in the response to the accumulation of damaged DNA. Because Chk1 activation requires its phosphorylation by ATR, it is expected that ATR or Chk1 ...
The fork and the kinase: A DNA replication tale from a CHK1 perspective
(Elsevier Science, 2015-01)
Replication fork progression is being continuously hampered by exogenously introduced and naturally occurring DNA lesions and other physical obstacles. Checkpoint kinase 1 (Chk1) is activated at replication forks that ...