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The prima donna of epigenetics: the regulation of gene expression by DNA methylation
(Associação Brasileira de Divulgação Científica, 2005)
Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation
(Elsevier, 2021)
Background: Inorganic lead (Pb) is common in the environment, and is toxic to neurological, renal, and cardiovascular systems. Pb exposure influences the epigenome with documented effects on DNA methylation (DNAm). We ...
Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: A promising tool for early detection of COPD and lung cancer in smokers
(2012)
Background: Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in ...
Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes
(Oxford University Press, 2020)
High-altitude adaptation is a classic example of natural selection operating on the human genome. Physiological and genetic adaptations have been documented in populations with a history of living at high altitude. However, ...
Screening methylation of DNA repair genes in the oral mucosa of chronic smokers
(2018-08-01)
Objective: The aim of this study was to evaluate the epigenetic changes in the process of oral carcinogenesis by screening the methylation of repair genes in chronic smokers. Design: Two groups were formed: Group 1: 16 ...
Nonsyndromic orofacial clefts in Chile: LINE-1 methylation and MTHFR variants
(Future Medicine, 2020)
Aim: To evaluate the risk of nonsyndromic orofacial clefts (NSOFCs) associated with LINE-1 methylation, as a marker of global DNA methylation, and the effect of MTHFR functional variants on this variable. Patients & methods: ...
Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation
(AME Publishing Company, 2017-04)
The presence of cfDNA in the circulating compartment was demonstrated three decades ago , leading to the emergence of liquid biopsy.However, the implementation of cfDNA methylation as a non-invasive molecular tool for the ...
Electron migration in DNA matrix: an electron transfer reaction
(Editora Unesp, 1998-01-01)
Este artigo apresenta uma área de pesquisa atual, ativa e interessante. Descreve a investigação da química de transferência de elétrons (TE) de um modo geral e resultados de TE em DNA em particular. Dois intercalantes de ...