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Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers
(Hindawi Publishing, 2015)
Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. It is a multifactorial disease, and its development depends ...
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients
(Academic Press Inc., 2018)
© 2018 Elsevier Inc.Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial ...
Folic acid supplementation during pregnancy induces sex-specific changes in methylation and expression of placental 11β-hydroxysteroid dehydrogenase 2 in rats
(Public Library of Science, 2015)
In the placenta, 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) limits fetal glucocorticoid exposure and its inhibition has been associated to low birth weight. Its expression,
encoded by the HSD11B2 gene is regulated ...
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
(Biomed Central Ltd., 2017)
Background: Multiple aberrant microRNA expression has been reported in gastric cancer. Among them, microRNA-335-5p (miR-335), a microRNA regulated by DNA methylation, has been reported to possess both tumor suppressor and ...
Environmental signaling and evolutionary change: Can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos?
(2005)
DNA methylation is one of the epigenetic and hereditary mechanisms regulating genetic expression in mammalian cells. In this review, we propose how certain natural agents, through their dietary consumption, could induce ...
Methylation status in healthy subjects with normal and high serum folate concentration
(ELSEVIER, 2008-12)
Objective: We assessed the impact of high serum folate concentration oil erythrocyte S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) concentrations, SAM/SAH ratio, CpG methylation levels across the promoter region ...
Cyclic AMP affects oocyte maturation and embryo development in prepubertal and adult cattle
(2016)
High cAMP levels during in vitro maturation (IVM) have been related to improved blastocyst yields. Here, we employed the cAMP/cGMP modulators, forskolin, IBMX, and cilostamide, during IVM to unravel the role of high cAMP ...
Softepigen : Primers design web-based tool for MS-HRM technique
(2018-08-29)
Polymerase Chain Reaction (PCR) based techniques for DNA methylation techniques includes MS-HRM technique. Methylation Sensitive High-Resolution Melting (MS-HRM) primer-design requires a set of necessary recommendations ...
Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes Identificación de asociaciones clínico-patológicas e hipermetilación de genes supresores de tumor
(2007)
Background: Methylation is an inactivation mechanism for tumor suppressor genes, that can have important clinical implications. Aim: To analyze the methylation status of 11 tumor suppressor genes in pathological samples ...