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Hepatocytes, rather than leukocytes reverse DNA damage in vivo induced by whole body y-irradiation of mice, as shown by the alkaline comet assay
(Sociedad de Biología de Chile, 2008)
Avaliação da importância do fotorreparo de DNA em anfíbios
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2019-02-19)
Amphibians have suffered a widespread population decline across the globe. About 40% of existing amphibian species are threatened with extinction. Solar ultraviolet (UV) radiation (280-400 nm) has the capacity to form ...
Role of estrogen and other sex hormones in brain aging: Neuroprotection and DNA repair
(Frontiers Research Foundation, 2017-12)
Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain ...
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
(NATURE PUBLISHING GROUPLONDON, 2012)
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylating downstream effectors. Although there has been a concerted effort to identify effectors of Chk1 activity, underlying mechanisms of ...
The sole DNA ligase in entamoeba histolytica is a high-fidelity DNA ligase involved in DNA damage repair
(Frontiers Media S.A., 2018)
Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells
(Elsevier Science, 2015-11)
Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a DNA repair enzyme that removes irreversible protein-linked 3′ DNA complexes, 3′ phosphoglycolates, alkylation damage-induced DNA breaks, and 3′ deoxyribose nucleosides. In addition ...
Hyperglycemia differentially affects maternal and fetal DNA integrity and DNA damage response
(2016-02-12)
Objective: Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. Methods: A total of 144 subjects were divided into 4 ...