Now showing items 31-40 of 792
Hepatocytes, rather than leukocytes reverse DNA damage in vivo induced by whole body y-irradiation of mice, as shown by the alkaline comet assay
(Sociedad de Biología de Chile, 2008)
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
(NATURE PUBLISHING GROUPLONDON, 2012)
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylating downstream effectors. Although there has been a concerted effort to identify effectors of Chk1 activity, underlying mechanisms of ...
Influence of diet on oxidative DNA damage, uracil misincorporation and DNA repair capability
(Oxford University Press, 2010-09-01)
The contribution of diet to cancer ranges from 10 to 80%. The low ingestion of antioxidants and enzymatic cofactors involved in DNA repair and methylation reactions and the high ingestion of chemical additives present in ...
Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes
Problem The most common DNA lesion generated by oxidative stress (OS) is 7, 8-dihydro-8-oxoguanine (8-oxoG) whose excision repair is performed by 8-oxoguanine glycosylase (OGG1). We investigated OGG1 expression changes in ...
Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells
(Elsevier Science, 2015-11)
Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a DNA repair enzyme that removes irreversible protein-linked 3′ DNA complexes, 3′ phosphoglycolates, alkylation damage-induced DNA breaks, and 3′ deoxyribose nucleosides. In addition ...
The intricate interplay between MSI and polymorphisms of DNA repair enzymes in gastric cancer H.pylori associated
(Oxford Univ Press, 2017-07-01)
Gastric cancer is the fourth most common type of cancer worldwide. Helicobacter pylori is a well-established risk factor and may cause injuries to genomic integrity through an inefficient DNA repair. This study aimed to ...
Hyperglycemia differentially affects maternal and fetal DNA integrity and DNA damage response
Objective: Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. Methods: A total of 144 subjects were divided into 4 ...
Response of the G2-prophase checkpoint to genotoxic drugs in lymphocytes from healthy individuals
(Society of Biology of Chile, 2012)
We analyzed the in vitro effects of the anti-tumoral drugs doxorubicin, cytosine arabinoside and hydroxyurea on the G2-prophase checkpoint in lymphocytes from healthy individuals. At biologically equivalent concentrations, ...
Screening methylation of DNA repair genes in the oral mucosa of chronic smokers
Objective: The aim of this study was to evaluate the epigenetic changes in the process of oral carcinogenesis by screening the methylation of repair genes in chronic smokers. Design: Two groups were formed: Group 1: 16 ...