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Inactivation of COX-2, HMLH1 and CDKN2A Gene by Promoter Methylation in Gastric Cancer: Relationship with Histological Subtype, Tumor Location and Helicobacter pylori Genotype
(Karger, 2011-01-01)
Objective: We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by promoter methylation and its relationship with the infection by different Helicobacter pylori strains in gastric cancer. Methods: DNA extracted ...
Inactivation of COX-2, HMLH1 and CDKN2A Gene by Promoter Methylation in Gastric Cancer: Relationship with Histological Subtype, Tumor Location and Helicobacter pylori Genotype
(Karger, 2011-01-01)
Objective: We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by promoter methylation and its relationship with the infection by different Helicobacter pylori strains in gastric cancer. Methods: DNA extracted ...
Epigenética e HVI-1: a participação das histonas na infecção e no tratamento
(2010)
Previously used as retroviruses vector silencing, epigenetic assays have become a key for understanding high complexity phenomena that is not explained yet. The effect of DNA polymer interaction on intramolecular and ...
CDKN2A promoter hypermethylation in astrocytomas is associated with age and sex
(2013-06-12)
CDKN2A promoter hypermethylation has been widely related to many cancers. In astrocytomas, although CDKN2A (p16INK4A protein) is often inactivated, there are still some controversial issues regarding the mechanism by which ...
Photodegradation and phototoxicity of antibacterial agents and the new alternatives for the photo-inactivation of microorganisms
(Facultad Experimental de Ciencias de la Universidad del Zulia, 2011)
Phenotype–genotype correlations in hemophilia A carriers are consistent with the binary role of the phase between F8 and X-chromosome inactivation
(Wiley Blackwell Publishing, Inc, 2015-04)
Background: The recessive X-linked disorder hemophilia A (HA) is rarely expressed in female carriers, most of whom express about half of normal factor VIII activity (FVIII:C). Objective: To propose an integrative assessment ...
5meCpG Epigenetic Marks Neighboring a Primate-Conserved Core Promoter Short Tandem Repeat Indicate X-Chromosome Inactivation
(Public Library of Science, 2014-07)
X-chromosome inactivation (XCI) is the epigenetic transcriptional silencing of an X-chromosome during the early stages of embryonic development in female eutherian mammals. XCI assures monoallelic expression in each cell ...
Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers
(2012)
The DOK1 gene is a putative tumour suppressor gene located on the human chromosome 2p13 which is frequently rearranged in leukaemia and other human tumours. We previously reported that the DOK1 gene can be mutated and its ...
Novel DNA photocleavage properties of [Cr(NN)3]3+ complexes
(Elsevier Science, 2012-01)
The aim of this study was to investigate the ability of chromium(III) tris-diimine complexes, [Cr(NN)3]3+, to induce DNA photodamage and to examine its capability to impair the survival of irradiated bacteria with the ...
Hypermutation in burkholderia cepacia complex is mediated by DNA mismatch repair inactivation and is highly prevalent in cystic fibrosis chronic respiratory infection
(Elsevier Gmbh, 2014-08)
The Burkholderia cepacia complex (Bcc) represents an important group of pathogens involved in long-term lung infection in cystic fibrosis (CF) patients. A positive selection of hypermutators, linked to antimicrobial ...