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Electrochemical investigations on the capacity of flavonoids to protect DNA against damage caused by textile disperse dyes
(Elsevier B.V., 2014-03-01)
In previous work, the interaction of DNA with the textile dyes Disperse Orange 1 (DO1) and Disperse Red 1 (DR1), and their electrolysis products, resulted in significant changes in the characteristic oxidation peaks of the ...
Effect of thiol compounds on bleomycin-induced DNA and chromosome damage in human cells
(Heldref Publications, 2013-02)
Non-protein thiols are considered radioprotectors, preventing DNA damage by ionizing radiation. As bleomycin (BLM) is a radiomimetic agent it was proposed that thiols may prevent DNA damage produced by this antibiotic. ...
Fluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro.
(2004-07-01)
Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury to genetic material. ...
Novel properties of melanins include promotion of DNA strand breaks, impairment of repair, and reduced ability to damage DNA after quenching of singlet oxygen
(ELSEVIER SCIENCE INCNEW YORK, 2012)
Melanins have been associated with the development of melanoma and its resistance to photodynamic therapy (PDT). Singlet molecular oxygen (102), which is produced by ultraviolet A solar radiation and the PDT system, is ...
Paracoccidioidomycosis: No genetic damage in human peripheral blood cells of patients assessed by single-cell gel (comet) assay
(2007-07-01)
Paracoccidioidomycosis is a systemic fungal infection caused by Paracoccidioides brasiliensis. As infectious diseases can cause DNA damage, the authors aimed at analyzing DNA breakage in peripheral blood cells of patients ...
Increased DNA damage is related to maternal blood glucose levels in the offspring of women with diabetes and mild gestational hyperglycemia
(2015-09-02)
This study aimed at correlating maternal blood glucose levels with DNA damage levels in the offspring of women with diabetes or mild gestational hyperglycemia (MGH). Based on oral glucose tolerance test results and glycemic ...
Relationship among oxidative DNA damage, gastric mucosal density and the relevance of cagA, vacA and iceA genotypes of Helicobacter pylori
(Springer, 2008-01-01)
The aim of this study was to evaluate the relationship among oxidative DNA damage, density of Helicobacter pylori and the relevance of cagA, vacA and iceA genotypes of H. pylori. Gastric epithelial cells were isolated from ...
DNA damage in peripheral blood mononuclear cells of patients undergoing anti-tuberculosis treatment
(Elsevier B.V., 2012-08-30)
Tuberculosis (TB), a chronic infectious disease, is a major cause of morbidity and mortality worldwide. Expression of iNOS and consequent production of NO during the inflammatory process is an important defense mechanism ...
DNA damage in patients infected by Helicobacter pylori
(American Association for Cancer Research (AACR), 2004-04-01)
Helicobacter pylori (H. pylori) is considered to predispose carriers to gastric cancer but its role on gastric carcinogenesis is still unknown. The aim of this study was to investigate DNA damage by the comet assay in ...