Now showing items 11-20 of 116
Identification of a New Hormone-Binding Site on the Surface of Thyroid Hormone Receptor
(Endocrine SocWashingtonEUA, 2014)
Identification of a new hormone-binding site on the surface of thyroid hormone receptor
(Endocrine SocietyChevy Chase, 2014-04)
Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily of ligand-activated transcription factors involved in cell differentiation, growth, and homeostasis. Although X-ray structures of many nuclear ...
A thermodynamic analysis of the binding specificity between four human pdz domains and eight host, viral and designed ligands
(MDPI AG, 2021-08)
PDZ domains are binding modules mostly involved in cell signaling and cell–cell junctions. These domains are able to recognize a wide variety of natural targets and, among the PDZ partners, viruses have been discovered to ...
3D-Pharma: uma ferramenta para triagem virtual baseada em fingerprints de farmacóforos
(Universidade Federal de Minas GeraisUFMG, 2012-06-18)
The pharmaceutical industry is going through a crisis of unheard proportions. Its cause can be related to the abrupt fall of new molecular entities approval by regulatory agencies, aggravated by the proximity of the ...
Electrochemical and Photophysical Properties of Ruthenium(II) Complexes Equipped with Sulfurated Bipyridine Ligands
(American Chemical Society, 2020-03)
The development of new solar-to-fuel scenarios is of great importance, but the construction of molecular systems that convert sunlight into chemical energy represents a challenge. One specific issue is that the molecular ...
A Computational Study of the Protein-Ligand Interactions in CDK2 Inhibitors: Using Quantum Mechanics/Molecular Mechanics Interaction Energy as a Predictor of the Biological Activity
(Biophysical SocietyBIOPOLIMERNueva York, Estados Unidos, 2022)