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The Renin–Angiotensin System Modulates Dopaminergic Neurotransmission: A New Player on the Scene
(Frontiers Media, 2021-06)
Parkinson’s disease (PD) is an extrapyramidal disorder characterized by neuronal degeneration in several regions of the peripheral and central nervous systems. It is the second most frequent neurodegenerative disease after ...
Neuroimmune and inflammatory signals in complex disorders of the central nervous system
(Karger, 2019-02)
An extensive microglial-astrocyte-monocyte-neuronal cross talk seems to be crucial for normal brain function, development, and recovery. However, under certain conditions neuroinflammatory interactions between brain cells ...
Paediatric Langerhans Cell Histiocytosis Disease: Long-Term Sequelae in the Hypothalamic Endocrine System.
(Karger, 2021-11)
Langerhans cell histiocytosis (LCH) is a disorder of the mononuclear phagocyte system that can affect almost any organ and system. The most common central nervous system (CNS) manifestation in LCH is the infiltration of ...
Brain angiotensin II involvement in chronic mental disorders
(Bentham Science Publishers, 2017-07)
Background: The functioning of the central nervous system is complex and it implies tight and coordinated interactions among multiple components. Neurotransmitters systems imbalance is a hallmark in the central nervous ...
Neurobiología de la glía y sus funciones en el desarrollo, la fisiología y la patología del SNCThe Neurobiology of Glial Cells and the Function they Perform in the Development, Physiology and the Pathology of the Central Nervous System (CNS)
(Sciens, 2010-02)
En este artículo se realiza una revisión de las investigaciones más recientes donde las células gliales son los actores fundamentales en todos los aspectos del desarrollo del cerebro, en su función y la enfermedad. Mucho ...
Controlling cytoplasmic c-Fos controls tumor growth in the peripheral and central nervous system
(Springer/Plenum Publishers, 2012-06)
Some 20 years ago c-Fos was identified as a member of the AP-1 family of inducible transcription factors (Angel and Karin in Biochim Biophys Acta 1072:129-157, 1991). More recently, an additional activity was described for ...
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
(Elsevier Science, 2010-05-03)
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied ...
Examining the impact of bone pathology on type I Gaucher disease
(Taylor & Francis, 2014)
Gaucher disease (GD) is an autosomal recessively inherited lysosomal disorder caused by mutations in GBA gene leading to deficient activity of the lysosomal enzyme acid β-glucocerebrosidase. Phenotipically, 3 different ...
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
(Pergamon-Elsevier Science Ltd, 2001-01)
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival ...
Autoimmune Attack of the Neuromuscular Junction in Myasthenia Gravis: Nicotinic Acetylcholine Receptors and Other Targets
(American Chemical Society, 2019-04)
The nicotinic acetylcholine receptor (nAChR) family, the archetype member of the pentameric ligand-gated ion channels, is ubiquitously distributed in the central and peripheral nervous systems and its members are the targets ...