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Direct effects of colchicine on myocardial function - Studies in hypertrophied and failing spontaneously hypertensive rats
(Lippincott Williams & Wilkins, 1999-01-01)
The aging spontaneously hypertensive rat (SHR) is a model in which the transition from chronic stable left ventricular hypertrophy to overt heart failure can be observed. Although the mechanisms for impaired function in ...
Direct effects of colchicine on myocardial function - Studies in hypertrophied and failing spontaneously hypertensive rats
(Lippincott Williams & Wilkins, 1999-01-01)
The aging spontaneously hypertensive rat (SHR) is a model in which the transition from chronic stable left ventricular hypertrophy to overt heart failure can be observed. Although the mechanisms for impaired function in ...
Excessive training induces molecular signs of pathologic cardiac hypertrophy
(2018-11-01)
Chronic exercise induces cardiac remodeling that promotes left ventricular hypertrophy and cardiac functional improvement, which are mediated by the mammalian or the mechanistic target of rapamycin (mTOR) as well as by the ...
Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy
(2017)
Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has ...
Cardiac hypertrophy and structural and metabolic remodeling related to seasonal dormancy in the first annual cycle in tegu lizards
(Elsevier B.V., 2013-07-01)
Morpho-functional adjustments in the heart of juvenile tegu lizards (Tupinambis merianae) were analyzed at distinct seasonal periods to investigate how the demands of growth and of energy saving are reconciled during the ...
Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice
(Nature Publishing GroupNew YorkEUA, 2010)
Reactive oxygen and nitrogen species balance in the determination of thyroid hormones-induced cardiac hypertrophy mediated by renin-angiotensin system
(ELSEVIER IRELAND LTD, 2011)
Role of reactive oxygen species (ROS)/nitric oxide (NO) balance and renin-angiotensin system in mediating cardiac hypertrophy in hyperthyroidism was evaluated in an in vivo and in vitro experimental model. Male Wistar rats ...
High fat diet induce the expression of NOX4 and cardiac hypertrophy in mice
(2017)
Obesity is strongly associated to hypertension, hyperlipidemia, and diabetes, three conditions known to produce cardiac disease. Besides, there is also evidence that obesity produces direct effects on the cardiac muscle, ...
Nox2 upregulation and p38α mapk activation in right ventricular hypertrophy of rats exposed to long-term chronic intermittent hypobaric hypoxia
(MDPI, 2020)
One of the consequences of high altitude (hypobaric hypoxia) exposure is the development of right ventricular hypertrophy (RVH). One particular type of exposure is long-term chronic intermittent hypobaric hypoxia (CIH); ...
Pathological hypertrophy and cardiac dysfunction are linked to aberrant endogenous unsaturated fatty acid metabolism
(Public Library Science, 2018-03-01)
Pathological cardiac hypertrophy leads to derangements in lipid metabolism that may contribute to the development of cardiac dysfunction. Since previous studies, using high saturated fat diets, have yielded inconclusive ...