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Now showing items 11-20 of 37
Hybrid Formulations of Liposomes and Bioadhesive Polymers Improve the Hypotensive Effect of the Melatonin Analogue 5-MCA-NAT in Rabbit Eyes
(Public Library of Science, 2014-10)
For the treatment of chronic ocular diseases such as glaucoma, continuous instillations of eye drops are needed. However, frequent administrations of hypotensive topical formulations can produce adverse ocular surface ...
Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailability
(Future Medicine, 2010-01)
Children constitute the most challenging population in anti-HIV/AIDS pharmacotherapy. Efavirenz (EFV; aqueous solubility 4 µg/ml, bioavailability 40–45%) is a first-line agent in the pediatric therapeutic cocktail. The ...
Formulation and characterization of polysaccharide microparticles for pulmonary delivery of sodium cromoglycate
(Springer, 2017-07)
Sodium cromoglycate (SC) is an antiasthmatic and antiallergenic drug commonly used for chronic inhalation therapy, however many daily intakes are required due to the fast drug clearance from airways. For these reasons, ...
Determinación de la actividad diurética del extracto hidroalcohólico de hojas de Piper peltatum L. sobre Rattus norvegicus.
(Escuela Superior Politécnica de Chimborazo, 2018-11)
The objective of the research was to determine the diuretic activity of the hydroalcoholic extract of Piper peltatum L. leaves on Rattus norvegicus animal model. A phytochemical screening was carried out to determine the ...
Determinaciòn de la actividad diurética del extracto hidroalcohólico de raíz de Piper peltatum L. en Rattus norvegicus.
(Escuela Superior Politécnica de Chimborazo, 2019-01)
The objective of this research was to evaluate the diuretic activity of the hydroalcoholic extract of the root of Piper peltatum L., in laboratory albino rats (Rattus norvegicus). To evaluate the diuretic activity, 25 ...
Differential effects of natural Curcumin and chemically modified curcumin on inflammation and bone resorption in model of experimental periodontitis
(2018-07-01)
Objective: The purpose of this study was to compare the effects of the oral administration of natural curcumin and a chemically modified curcumin (CMC2.24) on osteoclast-mediated bone resorption, apoptosis, and inflammation ...
Desarrollo galénico y eficacia clínica de ivermectina en sistemas semisólidos para uso oral en equinosPharmaceutical development and clinical efficacy of ivermectin semisolid systems for oral oral administration in horses
(Universidad Nacional del Nordeste. Facultad de Ciencias VeterinariasRevista Veterinaria, 2018-09-25)
La ivermectina (IVM) es un compuesto prácticamente insoluble en agua y fácilmente soluble en solventes orgánicos. Su distribución en el organismo es buena pero la absorción oral es variable, siendo ésta una condición ...
Effects of Albendazole Sulphoxide on Embryonic, Foetal and Placental Parameters in Wistar Rats
(Sociedad Chilena de Anatomía, 2009)
Novel nelfinavir mesylate loaded d-α-tocopheryl polyethylene glycol 1000 succinate micelles for enhanced pediatric anti HIV therapy: In vitro characterization and in vivo evaluation
(Elsevier Science, 2014-11)
Worldwide more than 35 million people are living with Human Immunodeficiency Virus (HIV) where 3.3 million are children. This translates in approximately 700 new daily infections in children only in 2012. Prolonged High ...
Biological, Behavioral and Physiological Consequences of Drug-Induced Pregnancy Termination at First-Trimester Human Equivalent in an Animal Model
(Facultad de Medicina y Ciencia, 2019)
Given the significant physiological changes that take place during and resulting from pregnancy, as well as the relative absence of such information in relation to pregnancy termination, this study investigated the potential ...