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A toxina urêmica ácido guanidinicoacético inibe o metabolismo oxidativo dos neutrófilos de cães
(2015-01-01)
Among the uremic toxins proven to affect the neutrophil function in humans with chronic kidney disease (CKD), guanidine compounds stand out. To achieve a clearer understanding of the mechanisms that affect the immunity of ...
The uremic toxin methylguanidine increases the oxidative metabolism and accelerates the apoptosis of canine neutrophils
(2017-03-01)
We investigated the hypothesis that the increased concentration of plasma methylguanidine (MG) increases oxidative metabolism and accelerates apoptosis of neutrophils from dogs with chronic kidney disease (CKD). To achieve ...
Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum
(Public Library of Science, 2015)
Ocular pharmacology of topotecan and its activity in retinoblastoma
(Lippincott Williams, 2014-09)
Purpose: To review the ocular pharmacology and antitumor activity of topotecan for the treatment of retinoblastoma by an evaluation of different routes of administration. Methods: Systematic review of studies available at ...
DNA Topoisomerase 1α Promotes Transcriptional Silencing of Transposable Elements through DNA Methylation and Histone Lysine 9 Dimethylation in Arabidopsis
(Public Library Of Science, 2014-05)
RNA-directed DNA methylation (RdDM) and histone H3K9 dimethylation (H3K9me2) are related transcriptional silencing mechanisms that target transposable elements (TEs) and repeats to maintain genome stability in plants. RdDM ...
Celldeath: A tool for detection of cell death in transmitted light microscopy images by deep learning-based visual recognition
(Public Library of Science, 2021-06-24)
Cell death experiments are routinely done in many labs around the world, these experiments are the backbone of many assays for drug development. Cell death detection is usually performed in many ways, and requires time and ...
Caracterização funcional do gene Hus1 de Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2015-02-20)
The DNA damage response (DDR) is a coordinated mechanism of damage signaling, in which lesion detection leads to cell cycle arrest and recruitment of repair machinery. One branch of the DDR is activated by the ATR kinase. ...
High concentrations of glucose reduce the oxidative metabolism of dog neutrophils in vitro
(2013-02-06)
Background: Dogs are commonly affected by hyperglycemic conditions. Hyperglycemia compromises the immune response and favors bacterial infections; however, reports on the effects of glucose on neutrophil oxidative metabolism ...
Efeitos antitumorais da naringenina complexada com cobre (II) e 2,2 -bipiridina em células de câncer de mama
(Universidade Federal de São CarlosBRUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF, 2014-05-07)
Cancer, is the name given to a set of more than 100 diseases that have in common the uncontrolled growth of cells that invade tissues and organs. It is occurs for several reasons, among them changes in DNA that may be ...
High concentrations of glucose reduce the oxidative metabolism of dog neutrophils in vitro
(2013-02-06)
Background: Dogs are commonly affected by hyperglycemic conditions. Hyperglycemia compromises the immune response and favors bacterial infections; however, reports on the effects of glucose on neutrophil oxidative metabolism ...