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Bio-click chemistry: a bridge between biocatalysis and click chemistry
(2022)
The fields of click chemistry and biocatalysis have rapidly grown over the last two decades. The development of robust and active biocatalysts and the widespread use of straightforward click reactions led to significant ...
Expanding cyclitol structural diversity by biocatalysis and metalocatalysis. A click chemistry approach
(SPRINGER, 2011)
The palladium catalyzed cross-coupling reaction of phenyltrifluoroborate with a chemoenzymatically derived bromoazidoconduritol, combined with 1,3-dipolar cycloaddition, with a variety of alkynes is described. Fourteen new ...
Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols
(Royal Society of Chemistry, 2013-02)
A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium ...
From the molecule to the mole: improving heterogeneous copper catalyzed click chemistry using single molecule spectroscopy
(Royal Society of Chemistry, 2017-01)
Single molecule spectroscopy (SMS) inspired the optimization of a heterogeneous 'click' catalyst leading to enhanced yields of the Cu-catalyzed reaction of azides with terminal alkynes. Changes in SMS data after optimization ...
Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs.
(Elsevier Science Inc, 2014-01)
A series of 1,2,3-triazolylsterols was prepared from pregnenolone through reductive amination and copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry). The newly generated stereocenter of the key propargylamino ...
Copper nanoparticles in click chemistry: an alternative catalytic system for the cycloaddition of terminal alkynes and azides
(Pergamon-Elsevier Science Ltd, 2009-03)
Readily prepared copper nanoparticles have been found to effectively catalyse the 1,3-dipolar cycloaddition of a variety of azides and alkynes furnishing the corresponding 1,2,3-triazoles in excellent yields. Both the ...
Heterogeneous photocatalytic click chemistry
(American Chemical Society, 2016-10)
Copper-doped semiconductors are designed to photoassist the alkyne-azide cycloaddition catalysis by Cu(I). Upon irradiation, injection of electrons from the semiconductor into copper oxide nanostructures produces the ...
Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry
(Arkat USA, 2011-02)
A series of 4-[(triazolyl)methoxy]phenyl analogs of the phenoxyphenyl-substituted thiirane SB-3CT 1 was evaluated for its ability to inhibit gelatinases, members of the matrix metalloproteinase family of enzymes. The ...
Synthesis of 1,2,3-triazolylpyranosides through click chemistry reaction
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
We have developed an efficient method for the synthesis of functionalized C-glycosyl 1,2,3-triazoles through a Cu(1)-promoted azide-alkyne 1,3-dipolar cycloaddition between a TMS-protected C-alkynyl-glycoside and organic ...