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Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy
(Federation of American Societies for Experimental Biology, 2020-04)
Chemotherapy has been reported to upregulate sphingomylinases and increase cellular ceramide, often linked to the induction to cell death. In this work, we show that sublethal doses of doxorubicin and vorinostat still ...
Hexagonal phase with ordered acyl chains formed by a short chain asymmetric ceramide
(Elsevier Science, 2017-01)
Ceramides constitute a group of lipids with usually high melting temperature that also favor negative curvature in membranes when mixed with other lipids. The short chain C10:0 ceramide is an asymmetric lipid which consists ...
Long-term biopermanence of ceramides, cholesteryl esters, and ether-linked triglycerides with very-long-chain PUFA in the cadmium-damaged testis
(Elsevier Science, 2014-01)
Cadmium is known to harm rat testis by causing the dose-dependent apoptotic or necrotic death of seminiferous epithelium cells. Here we investigated how this affects the lipids with long-chain (C18-C22) and very-long-chain ...
Anandamide revisited: How cholesterol and ceramides control receptor-dependent and receptor-independent signal transmission pathways of a lipid neurotransmitter
(MDPI, 2018-06)
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and ...
Sphingolipids as emerging mediators in retina degeneration
(Frontiers Media S.A., 2019-06-11)
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions. Their roles in the retina have gained ...
Changes in ceramide metabolism are essential in Madin-Darby canine kidney cell differentiation
(American Society for Biochemistry and Molecular Biology, 2017-07)
Ceramides and complex sphingolipids with defined acyl-chain lengths play important roles in numerous cell processes. Six ceramide synthase isoenzymes (CerS1-6) are the key enzymes responsible for the production of the ...
Sphingolipids as critical players in retinal physiology and pathology
(American Society for Biochemistry and Molecular Biology, 2021-01)
Sphingolipids have emerged as bioactive lipids involved in the regulation of many physiological and pathological processes. In the retina, they have been established toparticipate in numerousprocesses, suchas neuronal ...
Alteration of sphingolipids in biofluids: Implications for neurodegenerative Diseases
(Multidisciplinary Digital Publishing Institute, 2019-07-21)
Sphingolipids (SL) modulate several cellular processes including cell death, proliferation and autophagy. The conversion of sphingomyelin (SM) to ceramide and the balance between ceramide and sphingosine-1-phosphate (S1P), ...
The many faces (and phases) of ceramide and sphingomyelin I – single lipids
(Springer Verlag, 2017-10)
Ceramides, the simplest kind of two-chained sphingolipids, contain a single hydroxyl group in position 1 of the sphingoid base. Sphingomyelins further contain a phosphocholine group at the OH of position 1 of ceramide. ...