Search
Now showing items 721-730 of 774
Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions
(2008)
Fucoidan, a natural polysaccharide extracted from brown seaweed, inhibits the myotoxic phospholipases A2 present in
the venoms of crotalid snakes. This study evaluated the influence of molecular weight on the ability of ...
Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
(2021-09)
Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle ...
Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms
(Biochimica et Biophysica Acta - Biomembranes vol 1848: 463–468, 2015-02)
We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae
(Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs)
composed ...
Skin Pathology Induced by Snake Venom Metalloproteinase: Acute Damage, Revascularization, and Re-epithelization in a Mouse Ear Model
(2008-10)
Viperid snakebite envenomation induces blistering and dermonecrosis. The pathological alterations induced by a snake venom metalloproteinase in the skin were investigated in a mouse ear model. Metalloproteinase BaP1, from ...
Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays
(En prensa, 2014-02-28)
Parenteral administration of animal-derived antivenoms constitutes the mainstay in the
treatment of snakebite envenomings. Despite the fact that this therapy has been available for over a century, the detailed understanding ...
Tissue Damage and Inflammation Induced by Snake Venoms
(2014-03-27)
Some characteristics of the local tissue damage and inflammatory reactions
induced by snake venoms were analyzed in a mouse model. Tissue damage was
studied by intravital, light, and electron microscopic techniques, and ...
The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-α and PGE2-dependent mechanisms
(2007-08)
BACKGROUND AND PURPOSE:
Matrix metalloproteinases (MMPs) have been implicated in joint tissue destruction in arthritis. However, MMPs have not been assigned a role in joint pain. We investigated the ability of BaP1, a ...
Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A2
(2005-10)
The in vitro effects of myotoxin III (MT-III), an Asp-49 catalytically-active phospholipase A(2), and myotoxin II (MT-II), a catalytically-inactive Lys-49 variant, isolated from Bothrops asper snake venom, on phagocytosis ...
Lys-49 phospholipases A2 as active enzymes for beta-arachidonoyl phospholipid bilayer membranes
(1997)
Phospholipases A2 containing Lys-49 have been reported to be extremely weak or
inactive as enzyme. We have recently shown that basic proteins I and II (BP-I and BP-II), Lys-
49-PLA2s isolated from the venom of Trimeresurus ...
Snake venomics, experimental toxic activities and clinical characteristics of human envenomation by Bothrocophias myersi (Serpentes: Viperidae) from Colombia
(2020)
Venoms of the viperid genus Bothrocophias, restricted to Colombia and Ecuador, are poorly known. Only a proteomic analysis of B. campbelli venom has been described. In this work we present a proteomic study of B. myersi ...