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Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism
(2010)
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
Measurement of interaction parameters between glutathione and β-lactam antibiotics : a polarographic approach
(1988)
The interaction of glutathione with four β-lactam antibiotics was studied by an AC polarographic procedure. The interaction stability constant and the coordination number were calculated from the AC polarographic data. The ...
Polarographic and microcalorimetric study of the interaction between glutathione and amoxycillin
(1988)
The enthalpies of the reaction between glutathione and amoxycillin have been measured directly using a flow microcalorimeter. Comparative results are obtained by using an ac polarographic method previously developed in our ...
Farmacocinética de medicamentos de uso pediátrico, visión actual
(2008)
Pharmacokinetics corresponds to the branch of pharmacology that studies the absorption, distribution,
biotransformation and excretion of drugs in the body, in order to proportionate a reference line for
interpretation ...
Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica
(Sociedad Médica de Santiago, 2017)
Pharmacogenomics is an emergent field aimed at tailoring pharmacological
therapy. Genetic polymorphisms can modify the expression and
function of enzymes and proteins involved in drug metabolism, affecting
absorption, ...
Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic
(ELSEVIER, 2005-10-15)
In order to find some relationship between genetic differences in metabolic activation and detoxification of environmental carcinogens and host susceptibility to chemically induced cancers, we have investigated the ...
Revisiting the oxidation of flavonoids: loss, conservation or enhancement of their antioxidant properties
(MDPI, 2022)
Flavonoids display a broad range of health-promoting bioactivities. Among these, their capacity to act as antioxidants has remained most prominent. The canonical reactive oxygen species (ROS)-scavenging mode of the antioxidant ...
Microsomal oxidative damage promoted by acetaminophen metabolism
(PERGAMON-ELSEVIER SCIENCE LTD., 2011-10)
Adverse reactions of acetaminophen have been associated to oxidative stress, which may be elicited by
reactive oxygen species (ROS) and/or production of the metabolite NAPQI. Both phenomena would arise
through the activity ...
Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure Farmacogenética del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióti
(2006)
Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development ...
Farmacogenética del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
(2006)
Pharmacogenetics is the study of genetically determined variations in
the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has
acquired great relevancy due to the development ...