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The pituitary TGFb1 system as a novel target for the treatment of resistant prolactinomas
(BioScientifica, 2016-03)
Prolactinomas are the most frequently observed pituitary adenomas and most of themrespond well to conventional treatment with dopamine agonists (DAs). However, a subsetof prolactinomas fails to respond to such therapies ...
On the binding of folic acid to food proteins performing as vitamin micro/nanocarriers
(Elsevier, 2018-06)
Folic acid (FA) encapsulation in protein matrices has been reported as a suitable method for preventing FA degradation upon storage or processing as well as to improve its bioavailability. The ability of β-lactoglobulin ...
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
(American Society of Hematology, 2012-02)
The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible ...
A comprehensive approach toward concomitant triclabendazole polymorphism in pharmaceutical products
(Elsevier, 2021-04)
Triclabendazole (TCB) is a highly effective and low-cost anti-parasitic active pharmaceutical ingredient (API) used in the treatment of fascioliasis, a neglected tropical disease caused by Fasciola hepatica. It belongs to ...
Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes
(John Wiley & Sons Ltd, 2011-11)
Background: Cyclodextrins (CDs) are able to enhance the solubility, stability and bioavailability of several bioactive hydrophobic compounds by complex formation. They can also be used for removal of undesired components ...
Current Knowledge on Selenium Biofortification to Improve the Nutraceutical Profile of Food: A Comprehensive Review
(American Chemical Society, 2020-03)
Selenium (Se) is an important micronutrient for living organisms, since it is involved in several physiological and metabolic processes. Se intake in humans is often low and very seldom excessive, and its bioavailability ...
Functionalized bridged silsesquioxane-based nanostructured microspheres: ultrasound-assisted synthesis and in vitro cytotoxicity characterization
(Springer, 2011-04)
Different kinds of polymers have been employed in medicine as biomaterials for different purposes. In recent years, considerable attention has been focused on the development of new drug-delivery systems in order to increase ...
β-cyclodextrin complexation as an approach to enhance the biopharmaceutical properties of Norfloxacin B Hydrate
(Elsevier, 2019-11)
Binary systems of Norfloxacin B Hydrate with β-CD were explored by reliable biopharmaceutical studies as potential candidates for the preparation of drug delivery systems. Initially, studies of antimicrobial activity and ...
Iron-caseinglycomacropeptide complexes: characterization and application in beverages
(Elsevier Science, 2020-12)
Complexing iron with organic compounds has been considered an alternative strategy to mitigate the problems associated with the level of bioavailable iron and the acceptability of products supplemented with this mineral. ...
Effect of sex and genotype of the host on the anthelmintic efficacy of albendazole microcrystals, in the CBi-IGE Trichinella infection murine model
(Cambridge University Press, 2021-11)
Albendazole (ABZ) is an anthelmintic pharmaceutical commonly used in the treatment of nematode infections. It is a Class II drug poorly water-soluble, with very low bioavailability, a feature particularly limiting to treat ...