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Uncoupling the Folding and Binding of an Intrinsically Disordered Protein
(Academic Press Ltd - Elsevier Science Ltd, 2018-08)
The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain of the myeloblastosis oncoprotein, c-Myb, and its ordered binding partner, KIX. A series ...
Conserved charged amino acids are key determinants for fatty acid binding proteins (FABPs)-membrane interactions. A multi-methodological computational approach
(Taylor & Francis, 2018-03)
Based on the analysis of the mechanism of ligand transfer to membranes employing in vitro methods, Fatty Acid Binding Protein (FABP) family has been divided in two subgroups: collisional and diffusional FABPs. Although the ...
Side Fenestrations Provide an "anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels
(American Chemical Society, 2017)
Identifying trypanosome protein-RNA interactions using RIP-Seq
(Humana Press, 2020)
Trypanosomatids rely primarily on post-transcriptional mechanisms for the control of gene expression, with regulation of RNA processing, localization, degradation and translation by RNA-binding proteins (RBPs). To determine ...
Leaving no stone unturned: Allosteric targeting of SARS-CoV-2 Spike protein at putative druggable sites disrupts human angiotensin-converting enzyme interactions at the receptor binding domain.
The systematic entry of SARS-CoV-2 into host cells, as mediated by its Spike (S) protein, is
highly essential for pathogenicity in humans. Hence, targeting the viral entry mechanisms
remains a major strategy for COVID-19 ...
Hexose transporter glut1 harbors several distinct regulatory binding sites for flavones and tyrphostins
(AMER CHEMICAL SOC, 2011)
The facilitative hexose transporter GLUT1 activity is blocked by tyrosine kinase inhibitors that include natural products such as flavones and isoflavones and synthetic compounds such as tyrphostins, molecules that are ...
Promiscuous interactions of human septins: the GTP binding domain of SEPT7 forms filaments within the crystal
(Elsevier BVAmsterdam, 2011-12)
We describe the purification, crystallization and structure for the GTP-binding domain of human septin 7 (SEPT7G). We show that it forms filaments within the crystal lattice which employ both the G and NC interfaces, similar ...