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Synthetic Studies toward (-)-Cleistenolide: Highly Stereoselective Synthesis of New gamma-Lactone Subunits
(Sociedade Brasileira de Química, 2022)
Effects of Interleukin-1β in Glycinergic Transmission at the Central Amygdala
(Frontiers Media S.A., 2021-03)
Interleukin-1β (IL-1β) is an important cytokine that modulates peripheral and central pain sensitization at the spinal level. Among its effects, it increases spinal cord excitability by reducing inhibitory Glycinergic and ...
Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes
(Nature Publishing Group, 2017-12)
The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit CaV1.2 with auxiliary subunits CaVα2δ and CaVβ. Its traffic has been shown to be controlled by these ...
Prolonged AT(1)R activation induces Ca(V)1.2 channel internalization in rat cardiomyocytes
(Nature Publishing Group, 2017)
The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit Ca(V)1.2 with auxiliary subunits Ca-V alpha 2 delta and Ca-V beta. Its traffic has been shown to be ...
Functional characterization and protein-protein interactions of trypanosome splicing factors U2AF35, U2AF65 and SF1
(Elsevier Science, 2009-04)
Early in the assembly of the spliceosome of eukaryotes the branch-point binding protein (BBP, also called SF1) recognizes the branch point sequence, whereas the heterodimer U2AF consisting of a 65 and a 35 kDa subunit, ...
KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular
(Academic Press Ltd - Elsevier Science Ltd, 2010-06)
Recent evidence shows that the auxiliary subunit KChIP2, which assembles with pore-forming Kv4-subunits, represents a new potential regulator of the cardiac calcium-independent transient outward potassium current (Ito) ...
Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex
(Wiley Blackwell Publishing, Inc, 2016-05)
Psychostimulant addiction is associated with dysfunctions in frontal cortex. Previous data demonstrated that repeated exposure to methamphetamine (METH) can alter prefrontal cortex (PFC)-dependent functions. Here, we show ...
Acute modulation of calcium currents and synaptic transmission by gabapentinoids
(Landes Bioscience, 2010-12)
Gabapentin and pregabalin are anticonvulsant drugs that are extensively used for the treatment of several neurological and psychiatric disorders. Gabapentinoids (GBPs) are known to have a high affinity binding to α2 δ-1 ...