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Downregulation of inducible nitric oxide synthase (iNOS) expression is implicated in the antiviral activity of acetylsalicylic acid in HCV-expressing cells
(2014)
Previously, we described that acetylsalicylic acid (ASA) decreases HCV expression, but the mechanisms involved have not been clearly established. We evaluated the participation of inducible nitric oxide synthase (iNOS) in ...
Expression of heme oxygenase-1 in dendritic cells elicits T cell activation and confers protective immunity against HSV in an in vivo skin infection model
(2023)
Los virus herpes simple tipo 1 (HSV-1) y tipo 2 (HSV-2) son altamente prevalentes en la población, en parte debido a su frecuente diseminación, aún desde individuos asintomáticos. La infección por HSV puede producir diversas ...
La depleción de las células T regulatorias aumenta el número de las células CD8 durante la infección con el virus del tumor mamario murinoRegulatory T cell depletion increases the number of CD8 cells during mouse mammary tumor virus infection
(Medicina (Buenos Aires), 2011-03)
El virus del tumor mamario murino (MMTV) es un retrovirus que se transmite durante la lactancia y que ha desarrollado estrategias para explotar y subvertir el sistema inmune. En un modelo de infección natural con MMTV hemos ...
AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication
(Wiley-liss, Div John Wiley & Sons Inc, 2016-10)
We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones. Combined knock down of chaperones or AR-12 treatment acted to reduce the ...
Síntese e atividade biológica in vitro de derivados triptamínicos e β-carbolínicos contendo o anel 4-tiazolidinona frente às células tumorais humas e ao Herpes simplex tipo 1 e, de derivados triazinos-indólicos frente à inibição da DYRK1A relacionadaSynthesis and biological in vitro activity of tryptamines and β-carbolines derivatives containing the 4-thiazolidinone ring against human tumor cells and the Herpes simplex type 1 virus and, triazinos-indole for inhibition of DYRK1A related to Alzhei
(Universidade Estadual de MaringáBrasilDepartamento de QuímicaPrograma de Pós-Graduação em QuímicaUEMMaringá, PRCentro de Ciências Exatas, 2018)
Anti-HIV activity of natural triterpenoids and hemisyntheticderivatives 2004–2009
(Springer, 2010-03-25)
The continued advance of HIV-AIDS
makes the development of relatively inexpensive,
freely accessible, and mechanistically more diverse
antiviral therapies an urgent need. Natural products
are, directly or indirectly, ...
Antiviral activity of curcumin-nanoemulsion associated with photodynamic therapy in vulvar cell lines transducing different variants of HPV-16
(2020-01-01)
Vulvar intraepithelial neoplasia (VIN) is associated with human papillomavirus (HPV) infection. Curcumin is a natural bioactive compound with antineoplastic properties. The use of nanoparticles containing curcumin could ...
Non-Viable Lactobacillus Casei Beneficially Modulates Poly I:C Immune Response in Co-Cultures of Human Cells
(Shiraz Inst Cancer Res, 2017-12)
Background: Polyinosinic:polycytidylic acid (Poly-IC) has been used as a viralstimulus to mimic in vivo and in vitro infection induced by some viruses. Objective: To determine whether non-viable Lactobacillus casei CRL431 ...
Avaliação estrutural e atividades antiproliferativa, antiviral, antiparasitária e antibacteriana dos peptídeos Stigmurina e TsAP-2 presentes na peçonha do escorpião Tityus stigmurus
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM DESENVOLVIMENTO E INOVAÇÃO TECNOLÓGICA EM MEDICAMENTOS, 2020-12-17)
The resistance to conventional drugs in diseases of infectious and neoplasic origin is
a serious public health problem worldwide, presenting high morbidity and mortality,
leading to an incessant search for new therapeutic ...