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A new acridone with antifungal properties against Candida spp. and dermatophytes, and antibiofilm activity against C. albicans
(2019-01-01)
Aim: The increase in the number of fungal infections worldwide, coupled with the limitations of current antifungal chemotherapy, demand the development of safe and effective new antifungals. Here, we presented the synthesis ...
Fungistatic action of N-acetylcysteine on candida albicans biofilms and its interaction with antifungal agents
(2020-07-01)
Therapies targeted to fungal biofilms, mainly against the matrix, and therapies that do not induce microbial resistance are relevant. N-acetylcysteine (NAC), a mucolytic agent, has shown antimicrobial action. This study ...
Candida species: Current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
(2013-01-01)
The incidence of fungal infections has increased significantly, so contributing to morbidity and mortality. This is caused by an increase in antimicrobial resistance and the restricted number of antifungal drugs, which ...
Effect of cold atmospheric plasma jet associated to polyene antifungals on Candida albicans biofilms
(MDPI, 2021-09-25)
: The increasing incidence of antifungal resistance represents a great challenge in the medical area and, for this reason, new therapeutic alternatives for the treatment of fungal infections are urgently required. Cold ...
Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model
(2016-09-01)
Paracoccidioides brasiliensis and P. lutzii belong to a group of thermodimorphic fungi and cause paracoccidioidomycosis (PCM), which is a human systemic mycosis endemic in South and Central America. Patients with this ...
Microplate alamarblue assay for paracoccidioides susceptibility testing
(2013-04-01)
CLSI method M27-A3 is not available for use with dimorphic fungi, such as those of the Paracoccidioides genus. In this study, we developed a microdilution method and added the alamarBlue reagent to test the responses of ...
Fungal peritonitis in patients undergoing peritoneal dialysis (PD) in Brazil: molecular identification, biofilm production and antifungal susceptibility of the agents
(2016-10-01)
This paper presents data on fungal peritonitis (FP) in patients undergoing peritoneal dialysis (PD) at the University Hospital of Botucatu Medical School, São Paulo, Brazil. In a total of 422 patients, 30 developed FP, ...
Effect of cold atmospheric plasma jet associated to polyene antifungals on candida albicans biofilms
(2021-10-01)
The increasing incidence of antifungal resistance represents a great challenge in the medical area and, for this reason, new therapeutic alternatives for the treatment of fungal infections are urgently required. Cold ...
In vitro activity of zinc oxide-eugenol and glass ionomer cements on Candida albicans
(2005-04-01)
The aim of this study was to evaluate in vitro the antimicrobial activity of glass ionomer (GIC) and zinc oxide-eugenol (ZOE) cements against Candida albicans. Standardized GIC and ZOE specimens were maintained in contact ...
New synthesis and biological evaluation of benzothiazole derivates as antifungal agents
(American Chemical Society, 2015-03-21)
In search of new antifungal agrochemicals that could replace commercially available, aryl-2-mercaptobenzothiazoles were synthesized. They were prepared by two methodologies, using both photostimulated reaction and microwave ...