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Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice
(Frontiers Media Sa, 2017-10-04)
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures. For ...
Molecular Docking Study of Enzyme-Substrate Interaction in the Synthesis of Anandamide Synergists
(SciMed Central, 2017-06)
We have previously reported the synthesis of a series of twenty N-fatty acylamines analogs of anandamide, fifteen of them novel, following an enzymatic approach, in very good yield and a chemoselective way. The cytotoxic ...
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed
(Wiley Blackwell Publishing, Inc, 2005-10)
In the isolated rat mesenteric bed, the 1 min perfusion with 100 nM anandamide, a concentration that did not evoke vasorelaxation, elicited an acute release of 165.1 ± 9.2 pmol nitric oxide (NO) that was paralleled by a ...
Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation
(Frontiers Media SA, 2018-12-01)
Endocannabinoids are a group of endogenous lipid mediators that act as ligands of cannabinoid and vanilloid receptors, activating multiple signal transduction pathways. Together with enzymes responsible for their synthesis ...
Efeito da anandamida nos movimentos de mascar no vazio induzidos por haloperidol em ratos: participação do receptor CB1
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2012-09-05)
Treatment with antipsychotic drugs may cause tardive dyskinesia in humans and orofacial dyskinesia in rodents. Although the dopaminergic system in basal ganglia has been implicated in these movement disorders, their ...