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Classical and hologram QSAR studies on a series of inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase
(2008)
Leishmaniasis and trypanosomiasis are major causes of morbidity and mortality in both tropical and subtropical regions of the world. The current available drugs are limited, ineffective, and require long treatment regimens. ...
Síntese via catálise de cobre, caracterização e estudo in silico de 3-selenocromonas
(Universidade Tecnológica Federal do ParanáCampo MouraoBrasilDepartamento Acadêmico de QuímicaLicenciatura em QuímicaUTFPR, 2018-12-05)
Heterocyclic compounds constitute an important class due to their possible biological applications. Chromones, a class of heterocycles having oxygen as the ring heteroatom, have promising properties since they can be used ...
Metabolic basis for thyroid hormone liver preconditioning: Upregulation of AMP-activated protein kinase signaling
(2012)
The liver is a major organ responsible for most functions of cellular metabolism and a mediator between dietary and endogenous sources of energy for extrahepatic tissues. In this context, adenosine-monophosphate- (AMP-) ...
Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells
(2013)
Skeletal muscle glucose uptake in response to exercise is preserved in insulin-resistant conditions, but the signals involved are debated. ATP is released from skeletal muscle by contractile activity and can autocrinely ...
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease
(Elsevier B.V., 2018)
© 2018 The Authors In the last few decades, many reports have suggested that mitochondrial function impairment is a hallmark of Alzheimer's disease (AD). Although AD is a neurodegenerative disorder, mitochondrial damage ...
Catecholamine release from isolated sensory neurons of cat petrosal ganglia in tissue culture
(Elsevier, 2003)
The petrosal ganglion (PG) is entirely constituted by the perikarya of primary sensory neurons, part of which innervates the carotid body via the carotid sinus nerve (CSN). Application of acetylcholine (ACh) or nicotine ...
Human chorionic gonadotropin and free beta subunits stimulate phospholipid methylation in intact rat Leydig cells
(1993)
The effect of human chorionic gonadotropin (hCG) on intact Leydig cell phospholipid methylation was
studied. Hormonal stimulation of rat Leydig cells increased the incorporation of[methyl-3H]methionine
into phospholipids ...
ATPase and ADPase activities in synovial membrane of equine metacarpophalangeal joint
(2002)
ATPase and ADPase activities capable of hydrolyzing nucleoside di- and triphosphates in the presence of Ca2+ are present in synovial membrane of metacarpophalangeal joint mainly associated to membrane fractions. These ...
Cyclic ADP-ribose activates caffeine-sensitive calcium channels from sea urchin egg microsomes
(1998)
Adenosine 5'-cyclic diphosphoribose [cyclic ADP-ribose (cADPR)], a metabolite of NAD+ that promotes Ca2+ release from sea urchin egg homogenates and microsomal fractions, has been proposed to act as an endogenous agonist ...
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries
There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the ...