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Chemical modulation of the metabolism of an endophytic fungal strain of Cophinforma mamane using epigenetic modifiers and amino-acids
(Elsevier, 2022)
Endophytic fungi are capable of producing a great diversity of bioactive metabolites. However, the presence of silent and lowly expressed genes represents a main challenge for the discovery of novel secondary metabolites ...
Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
(Biomed Central Ltd., 2009-07-10)
The dose-delivery schedule of conventional chemotherapy, which determines its efficacy and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and disease control in a significant number of ...
Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
(Biomed Central Ltd., 2009-07-10)
The dose-delivery schedule of conventional chemotherapy, which determines its efficacy and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and disease control in a significant number of ...
Modulation of polyketide biosynthetic pathway of the endophytic fungus, Anteaglonium sp. FL0768, by copper (II) and anacardic acid
(2018-12-01)
In an attempt to explore the biosynthetic potential of endosymbiotic fungi, the secondary metabolite profiles of the endophytic fungus, Anteaglonium sp. FL0768, cultured under a variety of conditions were investigated. In ...
Identification, Selection, and Enrichment of Cardiomyocyte Precursors
(Hindawi Publishing Corporation, 2013-01-01)
The large-scale production of cardiomyocytes is a key step in the development of cell therapy and tissue engineering to treat cardiovascular diseases, particularly those caused by ischemia. the main objective of this study ...
Impermanence of somatic embryogenesis: the effects of and solutions to gradual aging of peach palm (Bactris gasipaes Kunth) cultures in vitro
(2019)
Culturas embriogênicas podem ser cultivadas por anos, mas acumulam características deletérias ao longo do tempo: crescimento reduzido; aumento da necrose; estruturas aberrantes; maturação impedida; e, eventualmente, perda ...
Cardiomyogenic differentiation of bone marrow mesenchymal cells: role of cardiac extract from neonatal rat cardiomyocytes
(Elsevier, 2010-02)
Bone marrow mesenchymal stromal cells (BM-MSCs) with regenerative potential have been identified in heart. Whether these cells become new cardiac lineage cells by phenomena of transdifferentiation or fusion is also being ...
The reprimo-like gene is an epigenetic-mediated tumor suppressor and a candidate biomarker for the non-invasive detection of gastric cancer
(MDPI, 2020)
Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we evaluated the role of RPRML and whether its regulation by DNA methylation is a potential non-invasive biomarker of gastric cancer. RPRML ...
Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation
(Nature Publishing Group, 2013-08)
Alternative splicing contributes to cell type-specific transcriptomes. Here, we show that changes in intragenic chromatin marks affect NCAM (neural cell adhesion molecule) exon 18 (E18) alternative splicing during neuronal ...
Phenotypic instability and epigenetic variability in a diploid potato of hybrid origin, Solanum ruiz-lealii
(BioMed Central, 2009-02-20)
Background: The wild potato Solanum ruiz-lealii Brüch. (2n = 2x = 24), a species of hybrid origin, is endemic to Mendoza province, Argentina. Recurrent flower malformations, which varied among inflorescences of the same ...