Now showing items 1-10 of 91
Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants
(Pergamon-Elsevier Science Ltd, 2003-12)
In addition to their well known actions on monoamine reuptake, tricyclic antidepressants have been shown to modulate ligand-gated ion channels (LGICs). Since the muscle nicotinic acetylcholine receptor (AChR) has been the ...
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ...
The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha(1B)-adrenoceptors
(Pergamon-Elsevier B.V. Ltd, 2010-07-01)
Although it is long known that the tricyclic antidepressants amitriptyline, nortriptyline and imipramine inhibit the noradrenaline transporter and alpha(1)-adrenoceptors with similar affinities, which may lead to self-cancelling ...
A concise route to the azaspirodecane moiety of halichlorine and structurally related alkaloids
(Amer Chemical SocWashingtonEUA, 2005)
Background and objectives: Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically ...
Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders
Temporomandibular disorder (TMD) is characterized by a combination of symptoms affecting the temporomandibular joint and/or chewing muscles. The two most common clinical TMD symptoms are pain and dysfunction. Pain is usually ...
Diels-Alder reactions of 6-substituted 1-(p-nitrobenzoyl)-5,6-dihydro-2-pyridinones
(Georg Thieme Verlag KgStuttgartAlemanha, 2002)
Pharmacogenomics in chronic pain therapy: From disease to treatment and challenges for clinical practice
Pharmacogenomics (PGx) has emerged as an encouraging tool in chronic pain therapy. Genetic variations associated with drug effectiveness or adverse reactions (amitriptyline/nortriptyline/codeine/oxycodone/tramadol-CYP2D6, ...
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors
(Pergamon-Elsevier Science Ltd., 2005)