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The economic impact of introducing serotonin-noradrenaline reuptake inhibitors into the Brazilian national drug formulary: Cost-effectiveness and budget-impact analyses
(Adis International Ltd, 2007)
Objective: To determine the cost effectiveness, from the Brazilian Ministry of Health viewpoint, of three antidepressant classes for major depressive disorder (MDD), and the budget impact of introducing serotonin-noradrenaline ...
A New Methodology to Create Polymeric Nanocarriers Containing Hydrophilic Low Molecular-Weight Drugs: A Green Strategy Providing a Very High Drug Loading
(American Chemical Society, 2019)
To date, a large number of active molecules are hydrophilic and aromatic low molecular-weight drugs (HALMD). Unfortunately, the low capacity of these molecules to interact with excipients and the fast release when a ...
In vitro sensitivity of Botrytis cinerea to anthraquinone and anthrahydroquinone derivatives
(AMER CHEMICAL SOC, 2005-12-28)
The effect on mycelial growth of the fungus Botrytis cinerea of a set of structurally related tricyclic hydroquinones [9,10-dihydroxy-4,4-dimethyl-2,3,5,8-tetrahydroantracen-1(4H)-one and 9,10-dihydroxy-4,4-dimethyl-5,8- ...
Synthesis of 4-aryl-4,7,8,9-tetrahydro-6H-pyrazolo[3,4-b]quinolin-5-ones
(HETERO CORPORATION, 1998-05)
Reaction of 5-amino-3-methyl-1-phenylpyrazole (1a) and 5-amino-3-(4-chlorophenyl)-1H-pyrazole (1b) with dimedone (2) and p-susbstituted benzaldehydes 3 in ethanol, afforded in all cases tricyclic linear 4-aryl- ...
Complete assignment of the C-13 NMR spectra of 4,4-dimethylanthracene-1,9,10(4H)-trione and the regioisomeric monomethyl derivatives
(JOHN WILEY & SONS LTD, 2000-02)
The H-1 and C-13 NMR spectra of a set of structurally related tricyclic quinones consisting of 4,4-dimethylanthracene-1,9,10(4H)-trione (1), 4,4,6,7-tetramethylanthracene-1,9,10(4H)-trione (2) and the regioisomers 4,4,5- ...
Domino inverse electron demand Diels-Alder reactions of chromones with ethyl vinyl ether
(PERGAMON-ELSEVIER SCIENCE LTD, 2007-06-01)
E)-Ethyl 3-(4-oxo-4H-chromen-3-yi)acrylate (3), (E)-3-(4-oxo-4H-chromen-3-yl)-2-propenenitrile (12) and their 5-hydroxy-derivatives 11 and 13 undergo alternative, solvent dependent, domino reactions with ethyl vinyl ether. ...
Detección de potenciales riesgos en la prescripción de antidepresivos tricíclicos mediante un sistema de alertas clínicas en línea
(Asociación Colombiana de PsiquiatríaColombia, 2018-07-08)
Objetivos
Analizar el uso, las indicaciones y los riesgos potenciales de los antidepresivos tricíclicos empleando un sistema tecnológico de alertas clínicas en el momento de la prescripción.
Métodos
Estudio observacional ...
Elección del mejor antidepresivo en pacientes con cáncer de mama en tratamiento con tamoxifeno: revisión de la evidencia básica y clínica
(Sociedad Médica de Santiago, 2016)
Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed ...
Is fibromyalgia part of the climacteric syndrome?
(Elsevier Ireland Ltd, 2012)
© 2012 Elsevier Ireland Ltd. All rights reserved. Fibromyalgia syndrome (FMS) is a disorder usually affecting middle aged women, who complain of diffuse musculoskeletal aches, pains or stiffness associated with tiredness, ...
Mixed Depression: Clinical Features and Predictors of Its Onset Associated with Antidepressant Use
(S. Karger AG, Basel, 2014)
Background: Mixed depression (MxD) is narrowly defined in
the DSM-IV and somewhat broader in the DSM-5, although
both exclude psychomotor agitation as a diagnostic criterion.
This article proposes a clinical description ...