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The influence of extra-therapeutic social support on the association between therapeutic bond and treatment outcome
(Routledge Journals, Taylor & Francis Ltd, 2020-10)
Objective: Both good therapeutic bond as well as extra-therapeutic social support seem to enhance treatment outcomes. Some features of the therapeutic bond are similar to experiences in extra-therapeutic relationships ...
Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
(Taylor & Francis, 2021-01)
Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease ...
Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases
(Informa Healthcare, 2019-02)
Introduction: Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role ...
Novel therapeutic targets for arenavirus hemorrhagic fevers
(Future Medicine, 2011-01)
Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and ...
Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease
(Frontiers Media, 2020-07)
Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively ...
Chitosan/hydroxyapatite composite bone tissue engineering scaffolds with dual and decoupled therapeutic ion delivery: Copper and strontium
(Royal Society of Chemistry, 2019-07)
Therapeutic metal ions are a family of metal ions characterized by specific biological properties that could be exploited in bone tissue engineering, avoiding the use of expensive and potentially problematic growth factors ...
Development of Magoh protein-overexpressing HEK cells for optimized therapeutic protein production
(Journal of the Serbian Chemical Society, 2020-04)
In the pharmaceutical industry, the need for high levels of protein expression in mammalian cells has prompted the search for new strategies, including technologies to obtain cells with improved mechanisms that enhance its ...
Cortical and meningeal pathology in progressive multiple sclerosis: A new therapeutic target?
(Freund & Pettman Publishers, 2019-04)
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that involves an intricate interaction between the central nervous system and the immune system. Nevertheless, its etiology is still unknown. MS ...
Novel hybrid lipid nanocapsules loaded with a therapeutic monoclonal antibody – Bevacizumab – and Triamcinolone acetonide for combined therapy in neovascular ocular pathologies
(Elsevier Science, 2021-02)
The aim of this study was to design and develop a novel hybrid formulation based on lipid nanocapsules containing bevacizumab (BVZ), an effective therapeutic antibody, on the surface and triamcinolone acetonide (TA) in the ...
MRP4/ABCC4 as a new therapeutic target: meta-analysis to determine cAMP binding sites as a tool for drug design
(Bentham Science Publishers, 2017-12)
MRP4 transports multiple endogenous and exogenous substances and is critical not only for detoxification but also in the homeostasis of several signaling molecules. Its dysregulation has been reported in numerous pathological ...