Now showing items 1-10 of 87
Kinetics and mechanism of the reaction of a nitroxide radical (tempol) with a phenolic antioxidant
In the absence of redox-active transition metal ions, the removal of Tempol by Trolox occurs by a simple bimolecular reaction that, most probably, involves a hydrogen transfer from phenol to nitroxide. The specific rate ...
Antioxidant Properties of Plant Extracts: an EPR and DFT Comparative Study of the Reaction with DPPH, TEMPOL and Spin Trap DMPO
(Soc Brasileira Quimica, 2009-01-01)
This work presents a comparative study of the antioxidant activity of extracts from nine plant species belonging to the Brazilian flora - Swartzia langsdorffii, Machaerium villosum, Pterogyne nitens, Pera glabrata, Aegiphyla ...
Adverse effects of tempol on hidrosaline balance in rats with acute sodium overload
(Informa Healthcare, 2016-11)
We studied the effects of tempol, an oxygen radical scavenger, on hydrosaline balance in rats with acute sodium overload. Male rats with free access to water were injected with isotonic (control group) or hypertonic saline ...
Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation
(ELSEVIER SCIENCE INC, 2010)
Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating disease of the human central nervous system (CNS). Most of the knowledge about the pathogenesis of MS has been derived from murine models, such as ...
Inhibition of in vivo leishmanicidal mechanisms by tempol: Nitric oxide down-regulation and oxidant scavenging
(ELSEVIER SCIENCE INC, 2008)
Tempol (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy) has long been known to protect experimental animals from the injury associated with oxidative and inflammatory conditions. In the latter case, a parallel decrease in ...
Tempol Reduces Podocyte Apoptosis via PARP Signaling Pathway in Experimental Diabetes Mellitus
Inhibition of myeloperoxidase-mediated protein nitration by tempol: Kinetics, mechanism, and implications
(NATL ACAD SCIENCES, 2008)
Despite the therapeutic potential of tempol (4-hydroxy-2,2,6,6-tetra-methyl-1-piperidinyloxy) and related nitroxides as antioxidants, their effects on peroxidase-mediated protein tyrosine nitration remain unexplored. This ...