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A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
(Sociedad Chilena de Química, 2010)
Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action
(Humana Press, 2019-12)
To improve the anticancer activity of telmisartan, its structure has been modified by Zn(II) complexation giving [Zn(Telm)2(H2O)2]·2H2O (ZnTelm). The cytotoxic effect was measured on the human lung cancer cells (A549) and ...
Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan
(Future Medicine, 2021-01)
Background: Angiotensin II receptor blockers were designed as therapeutic agents to block the binding site of the angiotensin II receptor type 1 (AT1R). Methodology: The structure of telmisartan was modified by coordination ...
Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
(Genetics and Molecular Biology, 2013-03-04)
The PPARγ nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 diabetes. Nevertheless, the therapeutic value of the ...
Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease
(2020-11-11)
Periodontal disease (PD) is a prevalent inflammatory disease with the most severe consequence being the loss of the alveolar bone and teeth. We therefore aimed to evaluate the effects of telmisartan (TELM), an angiotensin ...
Telmisartan impairs the in vitro osteogenic differentiation of mesenchymal stromal cells from spontaneously hypertensive male rats
(2021-12-05)
Telmisartan (TELM) is an angiotensin II (Ang II) type 1 receptor (Agtr1) antagonist, with partial agonism for Pparg, and has been shown to affect bone metabolism. Therefore, the aim of this study was to investigate the ...
Sin título
(2021-02-19)
In the original article, there was a mistake in Figure 3 as published. On Figure 3 panel F, an error was made when assembling the representative imagens on the board, and the same image was included twice for the SHR Control ...
EFECTO DE TELMISARTÁN SOBRE EL COMPONENTE OXIDATIVO, INFLAMACIÓN Y LESIÓN TISULAR EN LA LESIÓN POR ISQUEMIA/REPERFUSIÓN EN RATAS.
(Biblioteca Digital wdg.biblioUniversidad de Guadalajara, 2018-01-01)
La lesión por isquemia-reperfusión es un fenómeno que se presenta en múltiples patologías y desencadena una serie de eventos que producen secuelas irreparables inclusive más graves que la isquemia por si sola y que en la ...
Losartan reduces liver expression of plasminogen activator inhibitor-1 (PAI-1) in a high fat-induced rat nonalcoholic fatty liver disease model
(Elsevier Ireland, 2009-09)
OBJECTIVE: To evaluate the effect of losartan-an angiotensin II type 1 receptor (AT1R) antagonist- and telmisartan-an AT1R blocker with insulin-sensitizing properties-, on the hepatic expression of plasminogen activator ...
Blood pressure response to six-minute walk test in hypertensive subjects exposed to high altitude: effects of antihypertensive combination treatment
(Elsevier, 2016)
Background: Limited evidence exists on blood pressure (BP) responses to exercise in hypertensive subjects exposed to high altitude, and on the effects of antihypertensive treatment in this setting. We aimed to asses BP ...