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Electrochemical characterization of tacrine, an antialzheimer's disease drug, and its determination in pharmaceuticals
(WILEY-V C H VERLAG GMBH, 2000-03)
Tacrine, 9-amino-1,2,3,4-tetrahydroacridine, an antialzheimer's disease agent was electrochemically studied and a polarographic method For its quantitative determination in pharmaceuticals was developed. Tacrine was ...
Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning
(Bentham Science Publishers, 2019)
Electrochemical characterization of tacrine, an antialzheimer's disease drug, and its determination in pharmaceuticals
(2000)
Tacrine, 9-amino-1,2,3,4-tetrahydroacridine, an antialzheimer's disease agent was electrochemically studied and a polarographic method for its quantitative determination in pharmaceuticals was developed. Tacrine was ...
Inhibition Mechanism of Rat alpha(3)beta(4) Nicotinic Acetylcholine Receptor by the Alzheimer Therapeutic Tacrine
(AMER CHEMICAL SOC, 2011)
Nicotinic acetylcholine receptors (nAChRs) were studied in detail in the past regarding their interaction with therapeutic and drug addiction related compounds. Using fast kinetic whole-cell recording, we have now studied ...
QSAR analysis on tacrine-related acetylcholinesterase inhibitors
(Biomed Central, 2014-06)
The evaluation of the clinical effects of Tacrine has shown efficacy in delaying the deterioration of the symptoms of Alzheimer's disease, while confirming the adverse events consisting mainly in the elevated liver ...
Combined therapy for alzheimer’s disease: Tacrine and PAMAM dendrimers co-administration reduces the side effects of the drug without modifying its activity
(Springer, 2020-03-25)
Alzheimer´s disease has become a public health priority, so an investigation of new therapies is required. Tacrine (TAC) was licensed for treatments; however, its oral administration caused hepatotoxicity, so it is essential ...