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Synaptic signals mediated by protons and acid sensing ion channels
(Veterinary and Human Toxicology, 2019-06)
Extracellular pH changes may constitute significant signals for neuronal communication. During synaptic transmission, changes in pH in the synaptic cleft take place. Its role in the regulation of presynaptic Ca2+ currents ...
Age-related alterations in mitochondrial physiological parameters and nitric oxide production in synaptic and non-synaptic brain cortex mitochondria
(Pergamon-Elsevier Science Ltd, 2011-08)
Brain aging has been associated with mitochondrial dysfunction and changes in nitric oxide levels. The aim of this study was to evaluate the susceptibility of synaptic and non-synaptic mitochondria to aging-dependent ...
Modulation of acid sensing ion channel dependent protonergic neurotransmission at the mouse calyx of Held
(Pergamon-Elsevier Science Ltd, 2020-07)
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. It has been reported that homomeric ASIC-1a channels are expressed in neurons of the medial nucleus of ...
Synaptic localization of acylpeptide hydrolase in adult rat telencephalon
(ELSEVIER IRELAND LTD, 2012)
Acylpeptide hydrolase (ACPH), a serine protease present in the central nervous system (CNS), is believed to have a function in modulating synaptic plasticity, cleavage of beta amyloid peptide and degradation of aggregated ...
C-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases
(2023-02)
Our ability to learn and remember depends on the active formation, remodeling, and elimination of synapses. Thus, the development and growth of synapses as well as their weakening and elimination are essential for neuronal ...
Gain modulation of synaptic inputs by network state in auditory cortex in vivo
(Society for Neuroscience, 2015-02)
The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia. These different states of cortical activation gain modulate ...
Editorial: Glial cells, maladaptive plasticity, and neurodegeneration: Mechanisms, targeted therapies, and future directions
(Frontiers Media S.A., 2021-04-30)
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience. Morphological organization of the CNS represents the basis for its functional properties underlying higher brain ...
The Spacing Effect for Structural Synaptic Plasticity Provides Specificity and Precision in Plastic Changes
(Society for Neuroscience, 2017-05)
In contrast to trials of training without intervals (massed training), training trials spaced over time (spaced training) induce a more persistent memory identified as long-term memory (LTM). This phenomenon, known as the ...
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease.
Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits. These abnormalities ...