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Lithium causes differential effects on postsynaptic stability in normal and denervated neuromuscular synapses
(Nature Research, 2021-12)
Lithium chloride has been widely used as a therapeutic mood stabilizer. Although cumulative evidence suggests that lithium plays modulatory effects on postsynaptic receptors, the underlying mechanism by which lithium ...
Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs
(John Wiley & Sons Inc, 2009-12)
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic ...
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
(Nature Publishing Group, 2015-02)
Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by covalently conjugating Nedd8 to specific targets. However, its role in neurons, nonreplicating postmitotic cells, remains unexplored. ...
Lithium causes diferential efects on postsynaptic stability in normal and denervated neuromuscular synapses
(Springer Nature, 2021)
Abstract: Lithium chloride has been widely used as a therapeutic mood stabilizer. Although cumulative evidence
suggests that lithium plays modulatory efects on postsynaptic receptors, the underlying mechanism
by which ...
Structure of excitatory synapses and GABA
(American Society for Biochemistry and Molecular Biology Inc., 2014)
Formation, maintenance, and activity of excitatory and inhibitory synapses are essential for neuronal network function. Cell adhesion molecules (CAMs) are crucially involved in these processes. The CAM neuroplastin-65 ...
The lipid habitats of neurotransmitter receptors in brain
(Elsevier Science, 2016-11)
Neurotransmitter receptors, the macromolecules specialized in decoding the chemical signals encrypted in the chemical signaling mechanism in the nervous system, occur either at the somatic cell surface of chemically excitable ...
Interaction between facilitation and depression at a large CNS synapse reveals mechanisms of short-term plasticity
(Society for Neuroscience, 2010-02)
The two fundamental forms of short-term plasticity, short-term depression and facilitation, coexist at most synapses, but little is known about their interaction. Here, we studied the interplay between short-term depression ...
Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse
(2018-12-11)
Complete activation of B cells relies on their capacity to extract tethered antigens from immune synapses by either exerting mechanical forces or promoting their proteolytic degradation through lysosome secretion. Whether ...