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Enhanced immunization techniques to obtain highly specific monoclonal antibodies
(2018-01-02)
Despite fast advances in genomics and proteomics, monoclonal antibodies (mAbs) are still a valuable tool for areas such as the evolution of basic research in stem cells and cancer, for immunophenotyping cell populations, ...
Multiple Tolerization Reduces Antibody Binding Against Tolerogen Cells: Implications for the Production of Monoclonal Antibodies
(2018-04-01)
We report an immunization technique that can update the production of monoclonal antibodies (mAbs): the multiple tolerization subtractive immunization (MTSI). A total of 10 BALB/C mice were used. Animals in group 1 received ...
Multiple Tolerization Subtractive Immunization (MTSI) Protocol: Effects on Mice and Monoclonal Antibody Specificity
(2021-12-07)
Monoclonal antibodies (mAbs) have been a valuable tool to elucidate several biological processes, such as stem cell differentiation and cancer, and contributed to virtually all areas of biomedical sciences. Yet, it remains ...
Obtenção de anticorpos monoclonais murinos reconhecedores de células tumorais prostáticas humanas
(Universidade Estadual Paulista (Unesp), 2017-04-06)
O câncer de próstata (CaP) é o mais diagnosticado e a segunda causa de morte por câncer entre os homens na América e nos países da Europa Ocidental. No Brasil, o número de novos casos de CaP estimado para o ano de 2016 foi ...
Expresión génica diferencial en células blancas de cabrilla sardinera Mycteroperca rosacea ante la infección experimental con Aeromonas hydrophila
(Centro de Investigaciones Biológicas del Noroeste, S.C., 2010)
Identification of novel vaccine candidates for Chagas’ disease by immunization with sequential fractions of a trypomastigote cDNA expression library
(Elsevier, 2009-02)
The protozoan Trypanosoma cruzi is the etiological agent of Chagas´ disease, a major chronic infection in Latin America. Currently, there are neither effective drugs nor vaccines for the treatment or prevention of the ...
Cutaneous hypersensitivity induced in dogs and guinea-pigs by extracts of the tick Rhipicephalus sanguineus (Acari: Ixodidae)
(1995-12-01)
The cutaneous hypersensitivity induced by Rhipicephalus sanguineus tick extract in dogs (natural host) and guinea-pigs (laboratory host) was evaluated. The left ear of infested and control (tick-bite naive) dogs and ...