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N-Acyl Chain in Ceramide and Sphingomyelin Determines Their Mixing Behavior, Phase State, and Surface Topography in Langmuir Films
(American Chemical Society, 2014-06)
Sphingolipids are membrane lipids composed by a long chain aminediol base, usually sphingosine, with a N-linked fatty acyl chain whose quality depends on the membrane type. The effect of length and unsaturation of the ...
Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1999)
These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration. Cholesterol and sphingomyelin ...
Unique thermal behavior of sphingomyelin species with nonhydroxy and 2-hydroxy very-long-chain (C28-C32) PUFAs
(American Society for Biochemistry and Molecular Biology, 2013-05)
In rat germ cells and spermatozoa, sphingomyelin (SM) contains molecular species with nonhydroxy (n) and 2-hydroxy (h) very-long-chain polyunsaturated fatty acids (V), the most abundant being SMs with (n- and h-) 28:4n-6, ...
Differential involvement of rat sperm choline glycerophospholipids and sphingomyelin in capacitation and the acrosomal reaction
(Elsevier France-editions Scientifiques Medicales Elsevier, 2010-12)
Rat spermatozoa main lipid classes and their fatty acids were studied to assess their possible changes in capacitation and the acrosomal reaction (AR), induced in vitro . Capacitation-associated protein tyrosine phosphorylation, ...
Sticholysin I–membrane interaction: An interplay between the presence of sphingomyelin and membrane fluidity
(Elsevier Science, 2014-01)
Sticholysin I (St I) is a pore-forming toxin (PFT) produced by the Caribbean Sea anemone Stichodactyla helianthus belonging to the actinoporin protein family, a unique class of eukaryotic PFT exclusively found in sea ...
Sphingomyelins and ceramides with very-long-chain PUFA are excluded from lowdensity, raft-like domains in differentiating spermatogenic cells
(American Society for Biochemistry and Molecular Biology, 2017-01-12)
Rat spermatogenic cells contain sphingomyelins (SM) and ceramides (Cer) with very long chain (VLC) PUFA, in nonhydroxylated (n-V) and 2-hydroxylated (h-V) forms. How these atypical species distribute among membrane fractions ...
Mechanical properties of bilayers containing sperm sphingomyelins and ceramides with very long-chain polyunsaturated fatty acids
(Elsevier Ireland, 2019-01)
Sphingomyelins (SM) and ceramides (Cer) with very long chain polyunsaturated fatty acids (V) are important components of spermatozoa membranes. In this study, the mechanical properties of bilayers of SM and Cer with ...
The inhibition of sphingomyelin synthase 1 activity induces collecting duct cells to lose their epithelial phenotype
(Elsevier Science, 2018-02)
Epithelial tissue requires that cells attach to each other and to the extracellular matrix by the assembly of adherens junctions (AJ) and focal adhesions (FA) respectively. We have previously shown that, in renal papillary ...
Very long chain polyunsaturated fatty acids are the major acyl groups of sphingomyelins and ceramides located in the head of bull and rat spermatozoa
(American Society for Biochemistry and Molecular Biology, 2007-06)
Polyunsaturated fatty acids (VLCPUFA) are important constituents of sphingomyelin (SM) and ceramide (Cer) in testicular germ cells. In the present paper we focused on the SM and Cer and their fatty acids inspermatozoa and ...
The many faces (and phases) of ceramide and sphingomyelin I – single lipids
(Springer Verlag, 2017-10)
Ceramides, the simplest kind of two-chained sphingolipids, contain a single hydroxyl group in position 1 of the sphingoid base. Sphingomyelins further contain a phosphocholine group at the OH of position 1 of ceramide. ...