It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function…

We have recently described the expression and intracellular localization of ER α in murine C2C12 cells and skeletal muscle tissue. In separate studies, a protective role of 17β-estradiol against apoptosis exerted mainly ...

Erythropoietin acts by binding to its cell surface receptor on erythroid progenitor cells to stimulate erythrocyte production. Erythropoietin receptor expression in nonhematopoietic tissue, including skeletal muscle ...

17β-Estradiol exerts an antiapoptotic action in skeletal muscle cells through extranuclear ERα and β. This protective action, mainly involves a non-genomic mechanism of ERK1/2 and PI3K/Akt activation and BAD phosphorylation. ...

The hormone 17β-Estradiol (E2) acts on several non-reproductive tissues,including skeletal muscle. We have shown that E2 at physiological concentrations prevented apoptosis induced by hydrogen peroxide (H2O2) in skeletal ...

The voltage-gated calcium channel (Cav) β1a subunit (Cavβ1a) plays an important role in excitation-contraction coupling (ECC), a process in the myoplasm that leads to muscle-force generation. Recently, we discovered that ...

The classical model of 17β-estradiol action has been traditionally described to be mediated by the estrogen receptor (ER) localized exclusively in the nucleus. However, there is increasing functional evidence for extra ...

This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed ...