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Evolution of antitumor activity of 5 RNA interference in conjunction for the treatment of breast cancer in nude mice
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2022)
Use of small interfering RNA (siRNA) as a viral replication inhibitor of Human Herpesvirus 1 in BALB/C mice with keratoconjuntivitis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Recent advances in siRNA delivery mediated by lipid-based nanoparticles
Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for
the treatment of broad-spectrum intractable diseases. However, its unfavorable properties
such as easy degradation in the blood and ...
Regulación de la expresión génica mediada por piRNA en Gametogenesis masculina de mamíferos
(Universidad de Valparaíso, 2016-04)
A un grupo de RNAs pequeños no codificantes de proteínas se les ha denominado RNA interferentes, debido a la capacidad que tienen éstas moléculas para suprimir o disminuir la expresión de genes específicos mediante mecanismos ...
Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90
(2017-01-01)
Hepatitis C (HCV) is a viral disease affecting millions of people worldwide, and persistent HCV infection can lead to progressive liver disease with the development of liver cirrhosis and hepatocellular carcinoma. During ...
Genome-wide identification and characterization of tRNA-derived RNA fragments in land plants
(2017-01-01)
Key message: The manuscript by Alves et al. entitled “Genome-wide identification and characterization of tRNA-derived RNA fragments in land plants” describes the identification and characterization of tRNAderived sRNA ...
RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research
(2009)
Liver alcohol dehydrogenase oxidizes ethanol to acetaldehyde, which is further oxidized to acetate by aldehyde dehydrogenase-2 (ALDH2*1). Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde ...