Now showing items 1-10 of 29
Is the antidepressant activity of selective serotonin reuptake inhibitors mediated by nicotinic acetylcholine receptors?
(Molecular Diversity Preservation International, 2021-04)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates ...
Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors
(Pergamon-Elsevier Science Ltd, 2010-05)
Functional and structural approaches were used to examine the inhibitory mechanisms and binding site location for fluoxetine and paroxetine, two serotonin selective reuptake inhibitors, on nicotinic acetylcholine receptors ...
El síndrome serotoninérgico
(Universidad de Costa Rica, 2009)
Parkinson disease: Serotonin reuptake inhibitors for depression in PD
(Nature Publishing Group, 2012-07)
A recent study to investigate the safety and efficacy of serotonin reuptake inhibitors suggests that these drugs are beneficial for the treatment of depressive disorders in Parkinson disease. Whether these treatments will ...
(Universidad de Costa Rica, 2019)
Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
(JSciMed Central, 2017-02)
A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better ...
Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better ...
Positive regulation of raphe serotonin neurons by serotonin 2B receptors
(Nature Publishing Group, 2018-06)
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT2B receptors ...
Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes
(Pergamon-Elsevier Science Ltd, 2019-12)
The inhibitory activity of (±)-citalopram on human (h) α3β4, α4β2, and α7 nicotinic acetylcholine receptors(AChRs) was determined by Ca2+ influx assays, whereas its effect on rat α9α10 and mouse habenular α3β4*AChRs by ...
Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task
(Nature Publishing Group, 2021)
Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation ...