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Transcription factor engineering in CHO cells for recombinant protein production
(Taylor and Francis Ltd, 2019)
The continuous increase of approved biopharmaceutical products drives the development of more efficient recombinant protein expression systems. Chinese hamster ovary (CHO) cells are the mainstay for this purpose but have ...
Production of Cell-Penetrating Peptides in Escherichia coli Using an Intein-Mediated System
(Springer, 2015)
Cell-penetrating peptides are molecules with the ability to cross membranes and
enter cells. Attention has been put on these peptides as a tool for drug delivery research, as they
are able to serve as delivery vectors ...
Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
(Nature Publishing Group, 2016)
Certain types of glycolipids have been found to have remarkable immunomodulatory properties as a result of their ability to activate specific T lymphocyte populations with an extremely wide range of immune effector properties. ...
Global gene expression in recombinant and non-recombinant yeast Saccharomyces cerevisiae in three different metabolic states
(2009)
Global gene expression of two strains of Saccharomyces cerevisiae, one recombinant (P+), accumulating large
amounts of an intracellular protein Superoxide Dismutase (SOD) and one non-recombinant (P−) which does
not contain ...
GADD45α modulates DNA methylation induced by DNA damage during homologous recombination
(Biomédica, Mecatrónica y MecánicaEscuela de Ingeniería de Antioquia EIAUniversidad CES, 2014-04-23)
Homologous recombination is one of the major pathways for repairing DNA double strand breaks, the most
deleterious of DNA lesions. Recent studies suggest that DNA methylation events target homologous recombination ...
Design and implementation of a high yield production system for recombinant expression of peptides
(Bio Med Central, 2014)
Making peptide pharmaceuticals involves challenging processes where many barriers, which include production and manufacture, need to be overcome. A non common but interesting research area is related to peptides with ...
Peripheral T-Cell reactivity to heat shock protein 70 and its cofactor GrpE from tropheryma whipplei is reduced in patients with classical whipple's disease
(American Society for Microbiology, 2017)
Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward Tropheryma whipplei in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from T. whipplei ...
Trypanosoma cruzi calreticulin: In vitro modulation of key immunogenic markers of both canine tumors and relevant immune competent cells
(Elsevier, 2020)
Recombinant calreticulin from Trypanosoma cruzi (rTcCalr), the parasite responsible for Chagas' disease, binds to Canine Transmissible Venereal Tumor (CTVT) cells from primary cultures and to a canine mammary carcinoma ...
Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy
(Nature, 2014)
Background: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of
cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid ...