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Clinical and molecular study of a case of severe radio-sensitivity
(MedCrave, 2019-12)
A case of a patient with a breast intraductal tumor is presented. The patient underwent surgical quadrantectomy and axillary lymph node dissection and subsequently received Anthracycline treatment and 3D radiotherapy ...
Oligosaccharyltransferase inhibition reduces receptor tyrosine kinase activation and enhances glioma radiosensitivity
(American Association for Cancer Research, 2019-01)
Purpose: Parallel signaling reduces the effects of receptor tyrosine kinase (RTK)–targeted therapies in glioma. We hypothesized that inhibition of protein N-linked glycosylation, an endoplasmic reticulum co- and posttranslational ...
Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity
(2017-01-01)
Radiation therapy is widely used to treat human malignancies, but many tumor types, including gliomas, exhibit significant radioresistance. Radiation therapy creates DNA double-strand breaks (DSBs), and DSB repair is linked ...
Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells
(Elsevier B.V., 2017)
© 2017 Elsevier Inc. Osteosarcoma survival rate has not improved over the past three decades, and the debilitating side effects of the surgical treatment suggest the need for alternative local control approaches. Radiotherapy ...
Radiosensitivity enhancement of human thyroid carcinoma cells by the inhibitors of histone deacetylase sodium butyrate and valproic acid
(Elsevier Ireland, 2018-12)
Radiotherapy is one of the leading treatments for clinical cancer therapy. External beam radiotherapy has been proposed as an adjuvant treatment for patients bearing differentiated thyroid cancer refractory to conventional ...