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In vitro assembly of the feline immunodeficiency virus Gag polyprotein
(Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación, 2010)
The retroviral Gag protein is the only viral product that is necessary for the assembly of virions in mammalian cells. We have established an in vitro assembly system to study the assembly properties of purified feline ...
Comparing de novo and reference-based transcriptome assembly strategies by applying them to the blood-sucking bug Rhodnius prolixus
(Elsevier B. V., 2015-05-22)
High Throughput Sequencing capabilities have made the process of assembling a transcriptome easier, whether or not there is a reference genome. But the quality of a transcriptome assembly must be good enough to capture the ...
The Conserved Tyr176/Leu177 motif in the alpha-Helix 9 of the feline immunodeficiency virus capsid protein is critical for gag particle assembly
(Multidisciplinary Digital Publishing Institute, 2019-09-04)
The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. As a domain of Gag, it mediates the Gag–Gag interactions that drive immature particle assembly, whereas as a ...
Recent trends in protein and peptide-based biomaterials for advanced drug delivery
Abstract: Engineering protein and peptide-based materials for drug delivery applications has
gained momentum due to their favorable biochemical and biophysical properties over synthetic
materials, including biocompatibility, ...
The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles
(Springer, 2022-06-17)
Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent cations. This fact allows the cost-effective, large-scale generation of microscopic ...
The role of flow in the self-assembly of dragline spider silk proteins
(Elsevier, 2023)
Hydrodynamic flow in the spider duct induces conformational changes in dragline spider silk proteins (spidroins) and drives their assembly, but the underlying physical mechanisms are still elusive. Here we address this ...
Engineering protein nanoparticles out from components of the human microbiome
(Wiley VCH Verlag, 2020-07-28)
Nanoscale protein materials are highly convenient as vehicles for targeted drug delivery because of their structural and functional versatility. Selective binding to specific cell surface receptors and penetration into ...
Uncovering viral protein-protein interactions and their role in arenavirus life cycle
(MDPI, 2012-09)
The Arenaviridae family includes widely distributed pathogens that cause severe hemorrhagic fever in humans. Replication and packaging of their single-stranded RNA genome involve RNA recognition by viral proteins and a ...